Molecular structure of (−)-Nicotine ditartrate, CAS Number: 65-31-6
(−)-Nicotine ditartrate (CAS 65-31-6)
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Alternate Names:
(S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di-d-tartrate
Application:
(−)-Nicotine ditartrate is a potent agonist of AChR
CAS Number:
65-31-6
Purity:
>99%
Molecular Weight:
462.41
Molecular Formula:
C10H14N2•2C4H6O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(−)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine receptor). When nicotine binds to these receptors, it stimulates the release of neurotransmitters such as dopamine and serotonin. It also stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. (−)-Nicotine ditartrate has been used in a range of in vitro experiments, including studies on the effects of nicotine on cell cultures, the effects of nicotine on gene expression, and the effects of nicotine on enzyme activity.
(−)-Nicotine ditartrate (CAS 65-31-6) References
- Presynaptic nicotinic receptors modulating dopamine release in the rat striatum. | Wonnacott, S., et al. 2000. Eur J Pharmacol. 393: 51-8. PMID: 10770997
- NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function. | May-Simera, H. and Levin, ED. 2003. Brain Res Cogn Brain Res. 17: 475-83. PMID: 12880917
- Nicotine enhances responding with conditioned reinforcement. | Olausson, P., et al. 2004. Psychopharmacology (Berl). 171: 173-8. PMID: 13680077
- Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion. | Stier, CT., et al. 2004. Eur J Pharmacol. 495: 167-70. PMID: 15249166
- Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716). | Cohen, C., et al. 2005. Neuropsychopharmacology. 30: 145-55. PMID: 15292905
- Central nicotinic stimulation reduces vascular conductance in the gingiva in anesthetized rats. | Nakamura, T., et al. 2005. J Periodontal Res. 40: 67-72. PMID: 15613082
- Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. | Levin, ED., et al. 2005. Brain Res. 1041: 132-42. PMID: 15829222
- Electrochemical impedance spectroscopy for study of amyloid beta-peptide interactions with (-) nicotine ditartrate and (-) cotinine. | Szymańska, I., et al. 2007. Biosens Bioelectron. 22: 1955-60. PMID: 17000100
- The effect of varenicline on the development and expression of nicotine-induced behavioral sensitization and cross-sensitization in rats. | Goutier, W., et al. 2015. Addict Biol. 20: 248-58. PMID: 24251901
- A Genome-Wide Arrayed cDNA Screen to Identify Functional Modulators of α7 Nicotinic Acetylcholine Receptors. | Rex, EB., et al. 2017. SLAS Discov. 22: 155-165. PMID: 27789755
- Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine. | Rowell, PP. and Duggan, DS. 1998. Neuropharmacology. 37: 103-11. PMID: 9680263
- Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. | Levin, ED., et al. 1998. Pharmacol Biochem Behav. 61: 335-40. PMID: 9768569
Activator of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Nicotine ditartrate, 1 g | sc-203161 | 1 g | $90.00 | |||
(−)-Nicotine ditartrate, 5 g | sc-203161A | 5 g | $162.00 | |||
(−)-Nicotine ditartrate, 10 g | sc-203161B | 10 g | $206.00 | |||
(−)-Nicotine ditartrate, 25 g | sc-203161C | 25 g | $273.00 |