Molecular structure of (±)-Nicotine, CAS Number: 22083-74-5
(±)-Nicotine (CAS 22083-74-5)
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Alternate Names:
(±)-3-(1-Methyl-2-pyrrolidinyl)pyridine
Application:
(±)-Nicotine is an alkaloid found in tobacco with addictive and teratogenic properties
CAS Number:
22083-74-5
Purity:
≥97%
Molecular Weight:
162.23
Molecular Formula:
C10H14N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Nicotine is a chiral alkaloid compound that is of significant interest in neurobiological research due to its interaction with nicotinic acetylcholine receptors (nAChRs) in the brain. Studies involving (±)-Nicotine focus on elucidating the role of these receptors in cognitive processes such as memory and attention. In addition, this compound is used in investigations into the molecular basis of addiction, where it serves as a tool to understand the neurological pathways and receptor mechanisms involved in substance dependence. Researchers also employ (±)-Nicotine to explore its influence on neurotransmitter release, which is fundamental to the functioning of the central nervous system.
(±)-Nicotine (CAS 22083-74-5) References
- Nicotine transport in lung and non-lung epithelial cells. | Takano, M., et al. 2017. Life Sci. 188: 76-82. PMID: 28866099
- Discrimination of nicotine content in electronic cigarettes. | Perkins, KA., et al. 2019. Addict Behav. 91: 106-111. PMID: 29871789
- Nicotine arms race: JUUL and the high-nicotine product market. | Jackler, RK. and Ramamurthi, D. 2019. Tob Control. 28: 623-628. PMID: 30733312
- Chronic nicotine increases alcohol self-administration in adult male Wistar rats. | Montanari, C., et al. 2021. Psychopharmacology (Berl). 238: 201-213. PMID: 33000333
- Rewarding Effects of Nicotine Self-administration Increase Over Time in Male and Female Rats. | Chellian, R., et al. 2021. Nicotine Tob Res. 23: 2117-2126. PMID: 33987656
- Reinforcement enhancement by nicotine: A novel abuse-liability assessment of e-cigarettes in young adults. | Kirshenbaum, AP. and Hughes, JR. 2022. Exp Clin Psychopharmacol. 30: 959-972. PMID: 34166033
- Synthetic nicotine has arrived. | Jordt, SE. 2023. Tob Control. 32: e113-e117. PMID: 34493630
- Adolescents' Use of Nicotine-Free and Nicotine E-Cigarettes: A Longitudinal Study of Vaping Transitions and Vaper Characteristics. | Tokle, R., et al. 2022. Nicotine Tob Res. 24: 400-407. PMID: 34546348
- Comparison of nicotine emissions rate, 'nicotine flux', from heated, electronic and combustible tobacco products: data, trends and recommendations for regulation. | El Hourani, M., et al. 2022. Tob Control.. PMID: 35086911
- Sociodemographic differences in patterns of nicotine and cannabis vaping among US adults. | Mattingly, DT., et al. 2022. Prev Med Rep. 26: 101715. PMID: 35141121
- Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains. | Seemiller, LR., et al. 2022. Neuropharmacology. 221: 109279. PMID: 36208797
- Confidence in nicotine for tobacco harm reduction-Bridging the policy-practice gap. | Patwardhan, S. 2022. Drug Test Anal.. PMID: 36413490
- Non-nicotine constituents in cigarette smoke extract enhance nicotine addiction through monoamine oxidase A inhibition. | Liu, G., et al. 2022. Front Neurosci. 16: 1058254. PMID: 36507317
Activator of:
AChR α 3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Nicotine, 250 mg | sc-212379 | 250 mg | $370.00 | |||
(±)-Nicotine, 500 mg | sc-212379A | 500 mg | $735.00 | |||
(±)-Nicotine, 5 g | sc-212379B | 5 g | $7140.00 | |||
(±)-Nicotine, 10 g | sc-212379C | 10 g | $13770.00 |