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Nicotinamide (CAS 98-92-0)

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Alternate Names:
Niacinamide; Nicotinic Acid Amide; Pyridine-3-carboxylic acid amide
Application:
Nicotinamide is an NAD+ and NADP+ coenzyme precursor
CAS Number:
98-92-0
Purity:
≥98%
Molecular Weight:
122.10
Molecular Formula:
C6H6N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nicotinamide is a form of vitamin B3 and is employed in various research studies for its role in biochemistry and cellular metabolism. It is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in redox reactions and essential for ATP production. Researchers use Nicotinamide to study the NAD+ biosynthesis pathway and its impact on metabolic processes, as well as its role in the regulation of sirtuins, a class of proteins that depend on NAD+ and are implicated in gene silencing and longevity. In addition, Nicotinamide is used in enzymology to investigate the inhibition of poly(ADP-ribose) polymerases (PARPs), enzymes that utilize NAD+ in the repair of DNA damage. The compound has also been used in studies focused on circadian rhythms and the cellular aging process, given its influence on NAD+ levels and sirtuin activity.


Nicotinamide (CAS 98-92-0) References

  1. A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity.  |  Adak, S., et al. 2002. Proc Natl Acad Sci U S A. 99: 13516-21. PMID: 12359874
  2. Indirect electrochemical reduction of nicotinamide coenzymes.  |  Vuorilehto, K., et al. 2004. Bioelectrochemistry. 65: 1-7. PMID: 15522685
  3. Comparison of tissue preparation methods for assay of nicotinamide coenzymes.  |  Zhao, Z., et al. 1987. Plant Physiol. 84: 987-8. PMID: 16665633
  4. Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia.  |  Smesny, S., et al. 2007. Neuroimage. 35: 729-37. PMID: 17276699
  5. The effect of nicotinic acid amide on experimental tuberculosis of white mice.  |  McKENZIE, D. and MALONE, L. 1948. J Lab Clin Med. 33: 1249-53. PMID: 18886322
  6. Regeneration of nicotinamide coenzymes: principles and applications for the synthesis of chiral compounds.  |  Weckbecker, A., et al. 2010. Adv Biochem Eng Biotechnol. 120: 195-242. PMID: 20182929
  7. Antipsychotic drug effects on left prefrontal phospholipid metabolism: a follow-up 31P-2D-CSI study of haloperidol and risperidone in acutely ill chronic schizophrenia patients.  |  Smesny, S., et al. 2012. Schizophr Res. 138: 164-70. PMID: 22516552
  8. Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems.  |  Hummel, W. and Gröger, H. 2014. J Biotechnol. 191: 22-31. PMID: 25102236
  9. Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes.  |  Knaus, T., et al. 2016. J Am Chem Soc. 138: 1033-9. PMID: 26727612
  10. Donor-Acceptor Distance Sampling Enhances the Performance of 'Better than Nature' Nicotinamide Coenzyme Biomimetics.  |  Geddes, A., et al. 2016. J Am Chem Soc. 138: 11089-92. PMID: 27552302
  11. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate.  |  Beal, MF., et al. 1994. Ann Neurol. 36: 882-8. PMID: 7998775

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nicotinamide, 100 g

sc-208096
100 g
$44.00

Nicotinamide, 250 g

sc-208096A
250 g
$66.00

Nicotinamide, 1 kg

sc-208096B
1 kg
$204.00

Nicotinamide, 5 kg

sc-208096C
5 kg
$831.00

Hi, Could you please confirm the stability of Nicotinamide when reconstituted in water and stored at 4C.

Asked by: LauraF
Thank you for your question. We do not have information on the stability of this compound reconstituted. However, solutions typically have much shorter shelf lives, usually ranging from a few days to couple weeks at most. If you have any further questions, please contact Technical Service by email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2024-03-28
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Rated 5 out of 5 by from WeissWeiss, R. et al. (PubMed 26385774) demonstrated that Nicotinamide, an NAD+ and NADP+ coenzyme precursor, present during the differentiation of monocytes into granulocyte macrophage colony-stimulating factor, interferes with biochemical pathways resulting in strongly reduced pro-inflammatory features. -SCBT Publication Review
Date published: 2015-07-16
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Nicotinamide is rated 5.0 out of 5 by 1.
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