Date published: 2026-4-25

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Nicotelline (CAS 494-04-2)

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Alternate Names:
3,2′:4′,3′′-Terpyridine; Nicotellin
CAS Number:
494-04-2
Molecular Weight:
233.27
Molecular Formula:
C15H11N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nicotelline, a synthetic compound, has been specifically designed to emulate the effects of nicotine within the body. Although structurally similar to nicotine, nicotelline possesses distinct properties and effects. By binding to nicotinic acetylcholine receptors, which play a role in regulating various physiological functions, nicotelline initiates a series of events that lead to the release of neurotransmitters, including dopamine and norepinephrine. These neurotransmitters are responsible for the diverse effects exerted by nicotine on the body. Nicotelline′s interaction with nicotinic acetylcholine receptors mirrors nicotine′s impact, thus providing a means to mimic its physiological responses.


Nicotelline (CAS 494-04-2) References

  1. Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6.  |  Denton, TT., et al. 2004. Biochem Pharmacol. 67: 751-6. PMID: 14757175
  2. The effect of varying hormonal and precursor supplementations on levels of nicotine and related alkaloids in cell cultures ofNicotiana tabacum.  |  Lockwood, GB. and Essa, AK. 1984. Plant Cell Rep. 3: 109-11. PMID: 24253437
  3. Simultaneous determination of tobacco minor alkaloids and tobacco-specific nitrosamines in mainstream smoke by dispersive solid-phase extraction coupled with ultra-performance liquid chromatography/tandem orbitrap mass spectrometry.  |  Zhang, X., et al. 2018. Rapid Commun Mass Spectrom. 32: 1791-1798. PMID: 29964303
  4. Indexes of tobacco smoke contribution to environmental particulates based on molecular fingerprints of alkanes.  |  Cecinato, A., et al. 2022. Environ Sci Pollut Res Int. 29: 43048-43057. PMID: 35092585
  5. Tobacco-specific and combustion pollutants in settled house dust in Malta.  |  Aquilina, NJ., et al. 2022. J Environ Expo Assess. 1: PMID: 35497707
  6. Minor Tobacco Alkaloids as Biomarkers to Distinguish Combusted Tobacco Use From Electronic Nicotine Delivery Systems Use. Two New Analytical Methods.  |  Jacob, P., et al. 2022. Front Chem. 10: 749089. PMID: 35720984

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nicotelline, 5 mg

sc-212372
5 mg
$333.00