NHN1 Antibody (F-2): sc-514364

NHN1 Antibody (F-2) is a mouse monoclonal IgM kappa antibody that detects NHN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NHN1 (F-2) antibody is available as the non-conjugated form. NHN1 protein, also known as ZC3H18 (zinc finger CCCH domain-containing protein 18), is a crucial nuclear protein composed of 953 amino acids, featuring one C3H1-type zinc finger and existing in two alternatively spliced isoforms. NHN1 plays a significant role in RNA metabolism and regulation, which is vital for maintaining cellular homeostasis and responding to stress. NHN1 gene is located on human chromosome 16q24.2, a region associated with various genetic disorders, including giant axonal neuropathy, Rubinstein-Taybi syndrome, and Crohn′s disease, due to mutations in neighboring genes. Chromosome 16 encompasses over 900 genes and approximately 90 million base pairs, representing nearly 3% of the human genome. NHN1′s intricate interactions with other proteins involved in RNA processing underscore its importance in cellular function and disease mechanisms, making anti-NHN1 antibody (F-2) an essential tool for researchers studying gene expression and regulation in various biological contexts.

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NHN1 Antibody (F-2) References:

1. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.  |  Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
2. Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene.  |  Kuhlenbäumer, G., et al. 2002. Neurology. 58: 1273-6. PMID: 11971098
3. Genetics of inflammatory bowel disease: progress and prospects.  |  Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
4. Advances in the genetics of inflammatory bowel disease.  |  Cho, JH. 2004. Curr Gastroenterol Rep. 6: 467-73. PMID: 15527676
5. The Rubinstein-Taybi syndrome: occurrence in two sets of identical twins.  |  Baraitser, M. and Preece, MA. 1983. Clin Genet. 23: 318-20. PMID: 6682729
6. Rubinstein-Taybi syndrome caused by submicroscopic deletions within 16p13.3.  |  Breuning, MH., et al. 1993. Am J Hum Genet. 52: 249-54. PMID: 8430691
7. An unusual form of chronic neutropenia in a father and daughter with hypogammaglobulinaemia.  |  Mentzer, WC., et al. 1977. Br J Haematol. 36: 313-22. PMID: 889707

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NHN1 Antibody (F-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NHN1 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NHN1 Antibody (F-2) Specifications

Alternate Product Name: NHN1

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 341-358

Epitope Target: NHN1

Epitope Species: human

Product Reactivity/Detection: NHN1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NHN1 Antibody (F-2): P: Blocking Peptide