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NGIC-I is a cell permeable, selective indolocarbazole, which functions as an inhibitor of PKC (protein kinase C). Studies on human CMV (cytomegalovirus) show that UL97 kinases can be inhibited by NGIC-I. As a result of inhibition via NGIC-I on UL 97 kinases, formation of pp65-rich aberrant cytoplasmic tegument aggregate. Studies indicate that protein kinase C is involved in many signal cascades via their function to phosphorylate proteins. The ability to regulate this protein is very useful to control signal transduction cascades. NGIC-I is an inhibitor of cGKI.
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