Molecular structure of NGIC-I
NGIC-I
Application:
NGIC-I is a potent, cell-permeable, and selective PKC inhibitor
Purity:
≥95%
Molecular Weight:
364.4
Molecular Formula:
C23H16N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
NGIC-I is a cell permeable, selective indolocarbazole, which functions as an inhibitor of PKC (protein kinase C). Studies on human CMV (cytomegalovirus) show that UL97 kinases can be inhibited by NGIC-I. As a result of inhibition via NGIC-I on UL 97 kinases, formation of pp65-rich aberrant cytoplasmic tegument aggregate. Studies indicate that protein kinase C is involved in many signal cascades via their function to phosphorylate proteins. The ability to regulate this protein is very useful to control signal transduction cascades. NGIC-I is an inhibitor of cGKI.
NGIC-I References
- Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97. | Marschall, M., et al. 2001. J Gen Virol. 82: 1439-1450. PMID: 11369889
- Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy. | Marschall, M., et al. 2002. J Gen Virol. 83: 1013-1023. PMID: 11961255
- The protein kinase pUL97 of human cytomegalovirus interacts with and phosphorylates the DNA polymerase processivity factor pUL44. | Marschall, M., et al. 2003. Virology. 311: 60-71. PMID: 12832203
- Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80. | Fielding, PE., et al. 2004. Biochemistry. 43: 2578-86. PMID: 14992595
- The UL97 protein kinase of human cytomegalovirus and homologues in other herpesviruses: impact on virus and host. | Michel, D. and Mertens, T. 2004. Biochim Biophys Acta. 1697: 169-80. PMID: 15023359
- Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication. | Gershburg, E., et al. 2004. Antimicrob Agents Chemother. 48: 1900-3. PMID: 15105156
- Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity. | Herget, T., et al. 2004. Antimicrob Agents Chemother. 48: 4154-62. PMID: 15504835
- Identification of inhibitors for a virally encoded protein kinase by 2 different screening systems: in vitro kinase assay and in-cell activity assay. | Mett, H., et al. 2005. J Biomol Screen. 10: 36-45. PMID: 15695342
- Structural changes in human cytomegalovirus cytoplasmic assembly sites in the absence of UL97 kinase activity. | Azzeh, M., et al. 2006. Virology. 354: 69-79. PMID: 16872656
- Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation. | Romaker, D., et al. 2006. J Med Chem. 49: 7044-53. PMID: 17125257
- Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. | Hume, AJ., et al. 2008. Science. 320: 797-9. PMID: 18467589
- Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment. | Goldberg, MD., et al. 2011. J Virol. 85: 3375-84. PMID: 21248036
- Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells. | Wang, XZ., et al. 2023. PLoS Pathog. 19: e1011166. PMID: 36753521
Inhibitor of:
cGKI, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGIC-I, 500 µg | sc-222073 | 500 µg | $306.00 |