NGFR p75 Antibody (5H1): sc-71693
- NGFR p75 Antibody (5H1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against WM245 melanoma cells of human origin
- recommended for detection of NGFR p75 of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine, porcine, feline and canine
- See NGFR p75 (B-1): sc-271708 for NGFR p75 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for NGFR p75 Antibody (5H1) for WB and IHC(P) applications. This reagent is now offered in a bundle with NGFR p75 Antibody (5H1) (see ordering information below).
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NGFR p75 Antibody (5H1) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. NGFR p75, also known as the p75 neurotrophin receptor, plays a crucial role in the nervous system by modulating neuronal survival, differentiation, and apoptosis in response to neurotrophic factors. NGFR p75 is primarily located on the cell membrane of neurons and glial cells, where NGFR p75 interacts with neurotrophins like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). NGFR p75 is essential for proper signaling of these neurotrophins, as NGFR p75 enhances the affinity of Trk receptors, such as Trk A, for their ligands, thereby facilitating effective signal transduction. The interaction between NGFR p75 and Trk A not only accelerates the activation of Trk A but also aids in the recruitment of downstream signaling molecules, which are vital for neuronal health and function. Anti-NGFR p75 antibody (5H1) enables researchers to gain insights into the mechanisms of neurotrophic signaling and its implications in neurodegenerative diseases and neuronal development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGFR p75 Antibody (5H1) | sc-71693 | 200 µg/ml | $322.00 | |||
NGFR p75 Antibody (5H1): m-IgG1 BP-HRP Bundle | sc-542618 | 200 µg Ab; 20 µg BP | $361.00 |