Molecular structure of NGD 94-1, CAS Number: 179333-18-7
NGD 94-1 (CAS 179333-18-7)
Application:
NGD 94-1 is a high affinity D4 receptor ligand that is selective over D1, D2, D3, and D5 receptors
CAS Number:
179333-18-7
Molecular Weight:
320.39
Molecular Formula:
C18H20N6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NGD 94-1 is reported to be a high affinity D4 receptor ligand and is selective over D1, D2, D3 and D5 receptors. In transfected Chinese hamster ovary cells, additionally displays antagonist activity at the human D4.2 receptor. In HEK-293 cells displays agonist activity at the D4.4 receptor.
NGD 94-1 (CAS 179333-18-7) References
- Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. | Jentsch, JD., et al. 1999. Psychopharmacology (Berl). 142: 78-84. PMID: 10102786
- NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. | Gazi, L., et al. 1999. Eur J Pharmacol. 372: R9-10. PMID: 10395031
- Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor. | Gazi, L., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 361: 555-64. PMID: 10832611
- SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain. | Staley, JK., et al. 2000. Nucl Med Biol. 27: 547-56. PMID: 11056368
- Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. | Löber, S., et al. 2006. Bioorg Med Chem Lett. 16: 2955-9. PMID: 16563764
- Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion. | Albert, PR., et al. 1990. J Biol Chem. 265: 2098-104. PMID: 1688845
- Dopamine D₄ Receptor Antagonists for the Treatment of Cocaine Use Disorders. | Bergman, J. and Rheingold, CG. 2015. CNS Neurol Disord Drug Targets. 14: 707-15. PMID: 26022267
- Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists. | Boyfield, I., et al. 1996. J Med Chem. 39: 1946-8. PMID: 8642552
- I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor. | Tallman, JF., et al. 1997. J Pharmacol Exp Ther. 282: 1011-9. PMID: 9262370
- II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. | Primus, RJ., et al. 1997. J Pharmacol Exp Ther. 282: 1020-7. PMID: 9262371
- NGD 94-1: a specific dopamine-4-receptor antagonist. | Tallman, JF. 1998. Adv Pharmacol. 42: 490-2. PMID: 9327946
- Isoindolinone enantiomers having affinity for the dopamine D4 receptor. | Belliotti, TR., et al. 1998. Bioorg Med Chem Lett. 8: 1499-502. PMID: 9873377
- Selective dopamine D4 receptor antagonists | Sanner, M. A. 1998. Expert Opinion on Therapeutic Patents. 8(4): 383-393.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGD 94-1, 10 mg | sc-358837 | 10 mg | $138.00 | |||
NGD 94-1, 50 mg | sc-358837A | 50 mg | $607.00 |