Molecular structure of NGB 2904, CAS Number: 189060-98-8
NGB 2904 (CAS 189060-98-8)
Alternate Names:
NGB 2904 hydrochloride
Application:
NGB 2904 is a highly-selective D3DR antagonist
CAS Number:
189060-98-8
Molecular Weight:
530.92
Molecular Formula:
C28H29Cl2N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Highly-selective dopamine D3 receptor antagonist. Attenuates cocaine′s rewarding effects and inhibits relapse to drug-seeking behavior.
NGB 2904 (CAS 189060-98-8) References
- Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. | Gilbert, JG., et al. 2005. Synapse. 57: 17-28. PMID: 15858839
- The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. | Xi, ZX., et al. 2006. Neuropsychopharmacology. 31: 1393-405. PMID: 16205781
- Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. | Martelle, JL., et al. 2007. J Pharmacol Exp Ther. 321: 573-82. PMID: 17272677
- The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. | Pritchard, LM., et al. 2007. Pharmacol Biochem Behav. 86: 718-26. PMID: 17408730
- Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. | Xi, ZX. and Gardner, EL. 2007. CNS Drug Rev. 13: 240-59. PMID: 17627675
- The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. | Spiller, K., et al. 2008. Psychopharmacology (Berl). 196: 533-42. PMID: 17985117
- The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. | Thanos, PK., et al. 2008. Pharmacol Biochem Behav. 89: 499-507. PMID: 18329700
- Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904. | Banasikowski, TJ. and Beninger, RJ. 2012. Eur Neuropsychopharmacol. 22: 761-8. PMID: 22410316
- Low-dose polypharmacology targeting dopamine D1 and D3 receptors reduces cue-induced relapse to heroin seeking in rats. | Ewing, ST., et al. 2021. Addict Biol. 26: e12988. PMID: 33496050
- NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. | Yuan, J., et al. 1998. Bioorg Med Chem Lett. 8: 2715-8. PMID: 9873609
Inhibitor of:
D3DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGB 2904, 10 mg | sc-204127 | 10 mg | $189.00 | |||
NGB 2904, 50 mg | sc-204127A | 50 mg | $781.00 |