Date published: 2025-10-16

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NG,NG-Dimethylarginine Dihydrochloride (CAS 220805-22-1)

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Alternate Names:
ADMA
Application:
NG,NG-Dimethylarginine Dihydrochloride is a cell-permeable, reversible inhibitor of nitric oxide synthase
CAS Number:
220805-22-1
Purity:
≥98%
Molecular Weight:
275.18
Molecular Formula:
C8H18N4O22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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NG,NG-Dimethylarginine Dihydrochloride is a derivative of the amino acid arginine, which plays a role in the synthesis of proteins and the production of nitric oxide. It is involved in the regulation of nitric oxide production, which is important for various physiological processes such as vasodilation, neurotransmission, and immune response. NG,NG-Dimethylarginine Dihydrochloride is a competitive inhibitor of nitric oxide synthase, the enzyme responsible for the production of nitric oxide. It is used to set to study the role of nitric oxide in different biological systems and to investigate potential interventions targeting nitric oxide production. The capacity of NG,NG-Dimethylarginine Dihydrochloride to modulate nitric oxide levels enables it to contribute significantly to our understanding of the complex interaction of nitric oxide in biological systems.


NG,NG-Dimethylarginine Dihydrochloride (CAS 220805-22-1) References

  1. Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: clinical application in hypertensive subjects.  |  Gervasoni, J., et al. 2011. Clin Chem Lab Med. 49: 2109-15. PMID: 21892910
  2. Plasma biomarker discovery for early chronic kidney disease diagnosis based on chemometric approaches using LC-QTOF targeted metabolomics data.  |  Benito, S., et al. 2018. J Pharm Biomed Anal. 149: 46-56. PMID: 29100030
  3. Sulphurous thermal water inhalation impacts respiratory metabolic parameters in heavy smokers.  |  Carubbi, C., et al. 2019. Int J Biometeorol. 63: 1209-1216. PMID: 31227888
  4. Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.  |  Jayachandran, I., et al. 2020. Sci Rep. 10: 16005. PMID: 32994511
  5. Comparative physiological and metabolomic analyses reveal that Fe3O4 and ZnO nanoparticles alleviate Cd toxicity in tobacco.  |  Zou, C., et al. 2022. J Nanobiotechnology. 20: 302. PMID: 35761340
  6. Development of a novel Ultra Performance Liquid Chromatography Tandem-Mass Spectrometry (UPLC-MS/MS) method to measure l-arginine metabolites in plasma.  |  Santucci, L., et al. 2023. Clin Chim Acta. 543: 117306. PMID: 36990136
  7. Detection of NG,NG-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody.  |  Kimoto, M., et al. 1993. Arch Biochem Biophys. 300: 657-62. PMID: 8434946

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NG,NG-Dimethylarginine Dihydrochloride, 50 mg

sc-208093
50 mg
$261.00