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NG,NG′-Dimethy-L-arginine-d6 (CAS 1331888-08-4)

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Alternate Names:
N5-[(Dimethylamino)iminomethyl]-L-ornithine-d6
Application:
NG,NG′-Dimethy-L-arginine-d6 is An arginine derivative; used in chronic kidney diseases.A potential endogenous nitric oxide inhibitor in dialysis.
CAS Number:
1331888-08-4
Molecular Weight:
208.29
Molecular Formula:
C8H12D6N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

NG,NG′-Dimethyl-L-arginine-d6 is utilized in biochemical and physiological research, particularly focusing on its role in nitric oxide synthesis and regulation. This deuterated version of NG,NG′-Dimethyl-L-arginine is especially valuable in studies using stable isotope labeling to trace and quantify biological pathways involving arginine derivatives. Research involving NG,NG′-Dimethyl-L-arginine-d6 often explores its inhibitory effects on nitric oxide synthases, which are critical for understanding vascular function and regulation. Additionally, this compound is used in investigations of cardiovascular health, specifically looking at how altered nitric oxide production affects blood flow and pressure. Furthermore, NG,NG′-Dimethyl-L-arginine-d6 aids in the study of immune response mechanisms, providing insights into the modulation of immune cell activity through nitric oxide signaling pathways.


NG,NG′-Dimethy-L-arginine-d6 (CAS 1331888-08-4) References

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  2. Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan.  |  Azuma, H., et al. 1992. Br J Pharmacol. 106: 665-71. PMID: 1504750
  3. Rabbit aortic smooth muscle cell culture. A model for the pharmacological study of diabetes-induced alterations in cell proliferation.  |  Alipui, C., et al. 1991. J Pharmacol Methods. 26: 211-22. PMID: 1753745
  4. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.  |  Boulanger, C. and Lüscher, TF. 1990. J Clin Invest. 85: 587-90. PMID: 2153712
  5. Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney.  |  Ogawa, T., et al. 1989. J Biol Chem. 264: 10205-9. PMID: 2722865
  6. Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney.  |  Zhou, Y., et al. 2019. Life Sci. 224: 41-50. PMID: 30902543
  7. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase.  |  MacAllister, RJ., et al. 1996. Br J Pharmacol. 119: 1533-40. PMID: 8982498

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NG,NG′-Dimethy-L-arginine-d6, 1 mg

sc-208094
1 mg
$354.00

NG,NG′-Dimethy-L-arginine-d6, 10 mg

sc-208094A
10 mg
$2497.00