Molecular structure of NG-Hydroxy-L-arginine, Monoacetate Salt, CAS Number: 53598-01-9
NG-Hydroxy-L-arginine, Monoacetate Salt (CAS 53598-01-9)
Alternate Names:
NOHA acetate salt
Application:
NG-Hydroxy-L-arginine, Monoacetate Salt is an intermediate in the biosynthesis of nitric oxide
CAS Number:
53598-01-9
Molecular Weight:
250.25
Molecular Formula:
C6H14N4O3•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NG-Hydroxy-L-arginine, Monoacetate Salt is a cell-permeable, key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). It can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. It is also an inhibitor of Arginase.
NG-Hydroxy-L-arginine, Monoacetate Salt (CAS 53598-01-9) References
- Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline. | Boucher, JL., et al. 1992. Biochem Biophys Res Commun. 187: 880-6. PMID: 1530643
- Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells. | Zembowicz, A., et al. 1991. Proc Natl Acad Sci U S A. 88: 11172-6. PMID: 1662386
- N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. | Stuehr, DJ., et al. 1991. J Biol Chem. 266: 6259-63. PMID: 1706713
- Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro. | Vendrame, CM., et al. 2007. Scand J Immunol. 66: 287-96. PMID: 17635806
- Simultaneous determination of L-arginine and 12 molecules participating in its metabolic cycle by gradient RP-HPLC method: application to human urine samples. | Markowski, P., et al. 2007. Anal Chim Acta. 605: 205-17. PMID: 18036385
- Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. | Wells, SM., et al. 2009. Am J Respir Cell Mol Biol. 40: 179-88. PMID: 18703795
- The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. | Huynh, NN., et al. 2009. Br J Pharmacol. 156: 84-93. PMID: 19133993
- N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery. | Wallace, GC., et al. 1991. Biochem Biophys Res Commun. 176: 528-34. PMID: 2018542
- IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. | Riquelme, P., et al. 2013. Mol Ther. 21: 409-22. PMID: 22929659
- Oxidation of NG-hydroxy-L-arginine by nitric oxide synthase: evidence for the involvement of the heme in catalysis. | Pufahl, RA. and Marletta, MA. 1993. Biochem Biophys Res Commun. 193: 963-70. PMID: 7686757
- N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. | Boucher, JL., et al. 1994. Biochem Biophys Res Commun. 203: 1614-21. PMID: 7945311
- Normal And Reversed-Phase Thin-Layer Chromatography In The Analysis Of L -Arginine, Its Metabolites, And Selected Drugs | Irena Baranowska, et al. 2009. Journal of Planar Chromatography. 22: 89–96.
- Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark | Nadilla N. Atikasari, et al. 2020. Pharmacognosy Journal. 12: 227-231.
Inhibitor of:
Arginase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NG-Hydroxy-L-arginine, Monoacetate Salt, 5 mg | sc-222067A | 5 mg | $109.00 | |||
NG-Hydroxy-L-arginine, Monoacetate Salt, 25 mg | sc-222067 | 25 mg | $395.00 |