Molecular structure of NFκB Activation Inhibitor III, CAS Number: 380623-76-7
NFκB Activation Inhibitor III (CAS 380623-76-7)
See product citations (3)
Alternate Names:
3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide; SM 7368; SM-7368
Application:
NFκB Activation Inhibitor III is a TNF-α-stimulated NF kappa B activation inhibitor
CAS Number:
380623-76-7
Molecular Weight:
328.68
Molecular Formula:
C10H5ClN4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NF-κB Activation Inhibitor III is a thiazoloamide compound experimentally shown to inhibit TNF-α-stimulated NF-κB activation and MMP-9 in HT1080 upregulation. This upregulation corresponds to a concomitant inhibition of TNF-α-dependent cellular invasion. This compound has not been shown to affect the TNF-α-induced AP-1, occurring downstream of p38 activation.
NFκB Activation Inhibitor III (CAS 380623-76-7) References
- A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. | Lee, HY., et al. 2005. Biochem Biophys Res Commun. 336: 716-22. PMID: 16140265
- Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. | Kuntz, S., et al. 2010. Mol Nutr Food Res. 54: 1458-67. PMID: 20397192
- AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts. | Morizane, Y., et al. 2011. J Biol Chem. 286: 16030-8. PMID: 21402702
- Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells. | Sun, L., et al. 2013. Stem Cells. 31: 1454-66. PMID: 23592398
- Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. | Tian, Y., et al. 2013. Am J Pathol. 182: 2310-21. PMID: 23602832
- Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs. | Samuel, T., et al. 2014. BMC Cancer. 14: 599. PMID: 25134433
- TLR3 activation increases chemokine expression in human fetal airway smooth muscle cells. | Faksh, A., et al. 2016. Am J Physiol Lung Cell Mol Physiol. 310: L202-11. PMID: 26589477
- Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. | Onuma, W., et al. 2016. Oncotarget. 7: 8640-52. PMID: 26840084
- Anti-inflammatory and Neuroprotective Effects of Fungal Immunomodulatory Protein Involving Microglial Inhibition. | Chen, WY., et al. 2018. Int J Mol Sci. 19: PMID: 30469316
- Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD-L1 and MHC I in colon cancer cells. | Hassan, M., et al. 2023. Oncol Lett. 25: 41. PMID: 36589674
Inhibitor of:
C16orf46, EG216818, IκB-α, NF kappa B, and SPATA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFκB Activation Inhibitor III, 5 mg | sc-204818 | 5 mg | $115.00 |