NFATc2 Antibody (1): sc-136206
- NFATc2 Antibody (1) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 29-181 of NFATc2 of human origin
- recommended for detection of NFATc2 of human and canine origin by WB, IP and IF
- See NFATc2 (4G6-G5): sc-7296 for NFATc2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NFATc2 Antibody (1). This work is in progress.
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NFATc2 Antibody (1) is a mouse monoclonal IgG1 antibody that detects NFATc2 in human and canine samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). NFATc2, a crucial member of the NFAT family of transcription factors, plays a significant role in regulating cytokine gene expression in T cells, which is vital for the immune response. Upon T cell receptor activation, NFATc2 translocates from the cytoplasm to the nucleus, where NFATc2 collaborates with AP-1 transcription factors to initiate the transcription of various cytokine genes, thereby influencing T cell activation and differentiation. NFATc2′s importance extends beyond transcriptional activity; NFATc2 is also involved in the modulation of immune responses and has been implicated in various diseases, including autoimmune disorders and cancer. Understanding the dynamics of NFATc2 and NFATc2′s interactions with other proteins in the NFAT family, such as NFATc1 and NFATn, is essential for elucidating the complex regulatory networks that govern T cell function and the overall immune response. Anti-NFATc2 antibody (1) provides a powerful tool for researchers aiming to explore these critical pathways in both basic and applied immunology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NFATc2 Antibody (1) References:
- Cell fusion in skeletal muscle--central role of NFATC2 in regulating muscle cell size. | Pavlath, GK. and Horsley, V. 2003. Cell Cycle. 2: 420-3. PMID: 12963831
- NFATc2 is a potential therapeutic target in human melanoma. | Perotti, V., et al. 2012. J Invest Dermatol. 132: 2652-60. PMID: 22718120
- NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. | Bonami, RH., et al. 2014. Mol Immunol. 62: 321-8. PMID: 24507801
- Activation of Nfatc2 in osteoblasts causes osteopenia. | Zanotti, S. and Canalis, E. 2015. J Cell Physiol. 230: 1689-95. PMID: 25573264
- Identification of EWSR1-NFATC2 fusion in simple bone cysts. | Hung, YP., et al. 2021. Histopathology. 78: 849-856. PMID: 33316098
- FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. | Wang, J., et al. 2021. Theranostics. 11: 5045-5060. PMID: 33754043
- Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation. | Simonett, SP., et al. 2021. J Clin Invest. 131: PMID: 34491912
- Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress. | Darden, CM., et al. 2022. iScience. 25: 104125. PMID: 35402865
- Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma. | Gouda, MA., et al. 2023. Oncoscience. 10: 44-53. PMID: 37736255
- The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma. | Takeda, N., et al. 2024. Virchows Arch. 484: 533-538. PMID: 38483612
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFATc2 Antibody (1) | sc-136206 | 50 µg/0.5 ml | $316.00 |