Molecular structure of NFAT Activation Inhibitor III, CAS Number: 3519-82-2
NFAT Activation Inhibitor III (CAS 3519-82-2)
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Alternate Names:
INCA-6
Application:
NFAT Activation Inhibitor III is a potent and selective calcineurin-NFAT signaling inhibitor
CAS Number:
3519-82-2
Purity:
>95%
Molecular Weight:
284.3
Molecular Formula:
C20H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NFAT Activation Inhibitor III (INCA-6) is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. A quinone based compound that is cellularly permeable and blocks NFAT dephosphorylation. In experiments, this product particularly showed ability to prevent transient outward K+ current reduction in 3-Hz paced left ventricular cardiomyocytes following tachycardia. NFAT Activation Inhibitor III does not exhibit effects on calcineurin activity or calcineurin′s downstream signaling.
NFAT Activation Inhibitor III (CAS 3519-82-2) References
- Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. | Roehrl, MH., et al. 2004. Proc Natl Acad Sci U S A. 101: 7554-9. PMID: 15131267
- A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. | Roehrl, MH., et al. 2004. Biochemistry. 43: 16056-66. PMID: 15610000
- Discovery of small-molecule inhibitors of the NFAT--calcineurin interaction by competitive high-throughput fluorescence polarization screening. | Roehrl, MH., et al. 2004. Biochemistry. 43: 16067-75. PMID: 15610001
- P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. | Shiratori, M., et al. 2010. J Neurochem. 114: 810-9. PMID: 20477948
- Calcium regulates caveolin-1 expression at the transcriptional level. | Yang, XY., et al. 2012. Biochem Biophys Res Commun. 426: 334-41. PMID: 22940132
- The role of the NFAT signaling pathway in retinal neovascularization. | Bretz, CA., et al. 2013. Invest Ophthalmol Vis Sci. 54: 7020-7. PMID: 24052639
- Calcineurin inhibitors regulate fibroblast growth factor 23 (FGF23) synthesis. | Bär, L., et al. 2017. Naunyn Schmiedebergs Arch Pharmacol. 390: 1117-1123. PMID: 28761977
- The cardiac calsequestrin gene transcription is modulated at the promoter by NFAT and MEF-2 transcription factors. | Estrada-Avilés, R., et al. 2017. PLoS One. 12: e0184724. PMID: 28886186
- Mouse embryonic fibroblast (MEF)/BMP4-conditioned medium enhanced multipotency of human dental pulp cells. | Liu, L., et al. 2018. J Mol Histol. 49: 17-26. PMID: 29214501
- Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation. | Giblin, MJ., et al. 2021. Biochim Biophys Acta Mol Basis Dis. 1867: 166238. PMID: 34343639
Inhibitor of:
HLA-DRα, NFAM1, NFATc, NFATc1, NFATc2, NFATc3, and protein phosphatase (PPP3R1 PPP3R2).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFAT Activation Inhibitor III, 10 mg | sc-203160 | 10 mg | $117.00 |