Molecular structure of NF 546, CAS Number: 1006028-37-0
NF 546 (CAS 1006028-37-0)
Alternate Names:
4,4′-(Carbonylbis(imino-3,1-phenylen e-carbonylimino-3,1-(4-methyl-phenylene)carbonylim ino))-bis(1,3-xylene-alpha,alpha′-diphosphonic acid tetrasodium salt
Application:
NF 546 is a selective P2Y11 agonist that acts on multiple types of P2Y and P2X receptors
CAS Number:
1006028-37-0
Purity:
≥95%
Molecular Weight:
1180.74
Molecular Formula:
C47H44N6O17P4•4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
NF 546 has been shown to be a P2Y11 agonist that is selective for P2Y11 over a range of P2Y and P2X receptors.
NF 546 (CAS 1006028-37-0) References
- Purinergic signalling: what is missing and needed next? The use of transgenic mice, crystallographic analysis and MicroRNA. | Volonté, C., et al. 2012. CNS Neurol Disord Drug Targets. 11: 751-67. PMID: 22963439
- Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia. | Langfelder, A., et al. 2015. Cell Calcium. 57: 247-56. PMID: 25623949
- Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts. | Certal, M., et al. 2015. Cell Calcium. 58: 518-33. PMID: 26324417
- The effect of purinergic signaling via the P2Y11 receptor on vascular function in a rat model of acute inflammation. | Dănilă, MD., et al. 2017. Mol Cell Biochem. 431: 37-44. PMID: 28213772
- Coupling of P2Y receptors to Ca2+ mobilization in mesenchymal stromal cells from the human adipose tissue. | Kotova, PD., et al. 2018. Cell Calcium. 71: 1-14. PMID: 29604959
- Clopidogrel treatment inhibits P2Y2-Mediated constriction in the rabbit middle cerebral artery. | Kuszynski, DS., et al. 2021. Eur J Pharmacol. 911: 174545. PMID: 34606835
Inhibitor of:
P2Y10.Activator of:
P2X6, P2Y1, P2Y10, P2Y11, and PPAN-P2RY11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF 546, 10 mg | sc-361275 | 10 mg | $550.00 | |||
| US: Only available in the US | ||||||
NF 546, 50 mg | sc-361275A | 50 mg | $2000.00 | |||
| US: Only available in the US | ||||||