Molecular structure of NF 340, CAS Number: 202982-98-7
NF 340 (CAS 202982-98-7)
See product citations (5)
Alternate Names:
4,4′-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
Application:
NF 340 is a P2Y antagonist demonstrating 520-fold selectivity for P2Y over P2Y, P2Y2, P2Y4, P2Y6 and P2Y12 receptors
CAS Number:
202982-98-7
Purity:
≥95%
Molecular Weight:
986.84
Molecular Formula:
C37H26N4O15S4•4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NF 340 is a selective and potent P2Y11 antagonist that is used in research to study the purinergic signaling system. This compound aids in the investigation of the P2Y11 receptor′s role in various cellular processes, including ion channel regulation, energy metabolism, and apoptosis. Research involving NF 340 typically examines how P2Y11-mediated signaling influences immune responses, as the receptor is known to be expressed in immune cells and can impact inflammation and immune cell migration. NF 340 is also employed in the exploration of ATP′s extracellular functions, since P2Y11 receptors are activated by ATP, which serves as a signaling molecule in the extracellular space.
NF 340 (CAS 202982-98-7) References
- NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. | Meis, S., et al. 2010. J Pharmacol Exp Ther. 332: 238-47. PMID: 19815812
- Purine receptors and Ca(2+) signalling in the human blood-brain barrier endothelial cell line hCMEC/D3. | Bintig, W., et al. 2012. Purinergic Signal. 8: 71-80. PMID: 21956217
- Development of a comprehensive set of P2 receptor pharmacological research compounds. | Felix, RA., et al. 2012. Purinergic Signal. 8: 101-12. PMID: 22052555
- Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts. | Certal, M., et al. 2015. Cell Calcium. 58: 518-33. PMID: 26324417
- The effect of purinergic signaling via the P2Y11 receptor on vascular function in a rat model of acute inflammation. | Dănilă, MD., et al. 2017. Mol Cell Biochem. 431: 37-44. PMID: 28213772
- Coupling of P2Y receptors to Ca2+ mobilization in mesenchymal stromal cells from the human adipose tissue. | Kotova, PD., et al. 2018. Cell Calcium. 71: 1-14. PMID: 29604959
- Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. | Kinoshita, M., et al. 2018. EBioMedicine. 32: 72-83. PMID: 29887330
Inhibitor of:
P2Y11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF 340, 10 mg | sc-361274 | 10 mg | $245.00 | |||
| US: Only available in the US | ||||||
NF 340, 50 mg | sc-361274A | 50 mg | $976.00 | |||
| US: Only available in the US | ||||||