Molecular structure of NF 157, CAS Number: 104869-26-3
NF 157 (CAS 104869-26-3)
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Alternate Names:
8,8′-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Application:
NF 157 is an inhibitor of the P2Y11 receptor
CAS Number:
104869-26-3
Purity:
≥95%
Molecular Weight:
1437.08
Molecular Formula:
C49H28F2N6O23S6•6Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Decrease the expression of NAD+-induced activation of human granulocytes. NF157 is a robust purinergic receptor antagonist, effectively dampening the activity of the P2Y11 receptor (with an IC50 of 463 nM). What sets NF157 apart is its preference for targeting the P2Y11 and P2X1 receptors, showcasing selectivity over the P2Y1, P2Y2, P2X2, P2X3, P2X4, and P2X7 receptors. Notably, NF157 also curtails the NAD+-triggered activation of human granulocytes.
NF 157 (CAS 104869-26-3) References
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- CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells. | Kwan, HY., et al. 2010. J Vasc Res. 47: 148-56. PMID: 19729961
- Pharmacochemistry of the platelet purinergic receptors. | Jacobson, KA., et al. 2011. Purinergic Signal. 7: 305-24. PMID: 21484092
- The P2Y(2) nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells. | Ding, L., et al. 2011. J Biol Chem. 286: 27027-38. PMID: 21652710
- Development of a comprehensive set of P2 receptor pharmacological research compounds. | Felix, RA., et al. 2012. Purinergic Signal. 8: 101-12. PMID: 22052555
- Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes. | Jacobson, KA., et al. 2012. Wiley Interdiscip Rev Membr Transp Signal. 1: PMID: 23336097
- Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. | Kawano, A., et al. 2015. PLoS One. 10: e0127919. PMID: 26030257
- The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. | Ren, P., et al. 2014. Emerg Microbes Infect. 3: e62. PMID: 26038755
- An Essential and Synergistic Role of Purinergic Signaling in Guided Migration of Corneal Epithelial Cells in Physiological Electric Fields. | Nakajima, KI., et al. 2019. Cell Physiol Biochem. 52: 198-211. PMID: 30816668
- The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10. | Paulson, CN., et al. 2019. Open Biol. 9: 190117. PMID: 31409229
- Modeling early stage atherosclerosis in a primary human vascular microphysiological system. | Zhang, X., et al. 2020. Nat Commun. 11: 5426. PMID: 33110060
- P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications. | Woods, LT., et al. 2021. Biochem Pharmacol. 187: 114406. PMID: 33412103
Inhibitor of:
CD39L1, Gα s, P2Y11, and P2Y4.Activator of:
P2Y1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF 157, 1 mg | sc-204125 | 1 mg | $500.00 | |||
| US: Only available in the US | ||||||
NF 157, 5 mg | sc-204125A | 5 mg | $2040.00 | |||
| US: Only available in the US | ||||||