Neutral Red CAS: 553-24-2
MF: C15H17ClN4
MW: 288.78
A common histology stain used to determine cell viability..

Neutral Red (CAS 553-24-2)

Neutral Red | CAS 553-24-2 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-Amino-7-dimethylamino-2-methylphenazine hydrochloride; Basic Red 5; Toluylene red
Application: Neutral Red is a common histology stain used to determine cell viability.
CAS Number: 553-24-2
Molecular Weight: 288.78
Molecular Formula: C15H17ClN4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Neutral Red is most commonly used for histological stain for lysosymes but has also been incorporated in investigation of viruses, as a pH indicator, determination of DNA with optical and electrochemical methods, evalutaion of synthetic and naturally derived biomaterials. Neutral red can be electrochemically polymerized and used as a redox mediator. The compound once taken up by cells can be used to acertain cell viability with a excitation maximum at 470 nm and emission maximum at 580nm.


References

1. Antal, P., et al. 1995. Ann. Hematol. 70: 259-265. PMID: 7599287
2. Ricci, V., et al. 2002. Biochem. Biophys. Res. Commun. 292: 167-174. PMID: 11890688
3. Ni, Y., et al. 2006. Anal. Biochem. 352: 231-242. PMID: 16584704
4. Link, C.D., et al. 2006. J. Biol. Chem. 281: 1808-1816. PMID: 16239215

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml at 25° C), abs. alcohol (1.8%), and cellosolve (3.75%).
Storage :
Store at 4° C
Melting Point :
290° C (lit.)(dec.)
Boiling Point :
497.3° C at 760 mmHg
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
Internal ribosome entry site (IRES): IC50 = 20 nM (human); Huh-7: IC50 = 69.26 nM (human); β-Arrestin-1: IC50 = 8.88 µM (human); Cytoplasmic zinc-finger protein: IC50 = 13.00 µM (Caenorhabditis elegans); Apaf-1: IC50 = 34 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SG1400000
PubChem CID :
11105
Merck Index :
14: 6488
MDL Number :
MFCD00012651
EC Number :
209-035-8
Beilstein Registry :
3918740
SMILES :
CC1=CC2=NC3=C(C=C(C=C3)N(C)C)N=C2C=C1N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Neutral Red (CAS 553-24-2) Product Citations

See how others have used Neutral Red (CAS 553-24-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 10200307  Saito, A. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 4592-4597.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of Neutral Various publications cite the use of Neutral Red for histological staining of lysosymes, but it has also been incorporated in investigation of viruses, as a pH indicator, determination of DNA with optical and electrochemical methods, evaluation of synthetic and naturally derived biomaterials. -SCBT Publication Review
Date published: 2015-06-16
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