neuropilin-1 Antibody (A-12): sc-5307

Neuropilin Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody specifically targeting neuropilin, also known as NRP1 or neuropilin-1, of human, rat, and mouse origin. Anti-neuropilin antibody (A-12), which recognizes an epitope corresponding to amino acids 570-855 of human neuropilin, is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Neuropilin-1 is a type I transmembrane receptor that plays a crucial role in neural development by guiding axon growth and is also a high-affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF), making it key in both axonal guidance and angiogenesis. Neuropilin-1 is predominantly expressed in arterial endothelial cells, distinguishing it from its closely related homolog, neuropilin-2, which shares similar structural features but is found in venous and lymphatic endothelial cells. The differential expression of these neuropilins contributes to their distinct roles in vascular development and immune cell function. Neuropilin monoclonal antibody (A-12) is available in both unconjugated and conjugated forms, including variants linked to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes, providing flexibility for various experimental applications.

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neuropilin-1 Antibody (A-12) References:

1. Neuropilins in physiological and pathological angiogenesis.  |  Staton, CA., et al. 2007. J Pathol. 212: 237-48. PMID: 17503412
2. [Advancements in expression of vascular endothelial growth factor receptors in skin diseases].  |  Yang, XH., et al. 2007. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 29: 279-82. PMID: 17536285
3. Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.  |  Curreli, S., et al. 2007. J Biol Chem. 282: 30346-56. PMID: 17699524
4. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.  |  Cantuti-Castelvetri, L., et al. 2020. Science. 370: 856-860. PMID: 33082293
5. Neuropilin (NRPs) Related Pathological Conditions and Their Modulators.  |  Broz, M., et al. 2022. Int J Mol Sci. 23: PMID: 35955539
6. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.  |  Püschel, AW., et al. 1995. Neuron. 14: 941-8. PMID: 7748561
7. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord.  |  Messersmith, EK., et al. 1995. Neuron. 14: 949-59. PMID: 7748562
8. Axon guidance: a compelling case for repelling growth cones.  |  Dodd, J. and Schuchardt, A. 1995. Cell. 81: 471-4. PMID: 7758101
9. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.  |  Kolodkin, AL., et al. 1993. Cell. 75: 1389-99. PMID: 8269517
10. The guidance molecule semaphorin III is expressed in regions of spinal cord and periphery avoided by growing sensory axons.  |  Wright, DE., et al. 1995. J Comp Neurol. 361: 321-33. PMID: 8543665
11. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.  |  He, Z. and Tessier-Lavigne, M. 1997. Cell. 90: 739-51. PMID: 9288753
12. Neuropilin is a semaphorin III receptor.  |  Kolodkin, AL., et al. 1997. Cell. 90: 753-62. PMID: 9288754

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-neuropilin-1 Antibody (A-12) has 65 citations in a variety of scientific publications.

Primary antibodies like Anti-neuropilin-1 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

neuropilin-1 Antibody (A-12) Specifications

Alternate Product Name: neuropilin

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 570-855

Epitope Target: neuropilin

Epitope Species: human

Product Reactivity/Detection: neuropilin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 65 citations in various scientific publications

Available Conjugates/Forms for neuropilin-1 Antibody (A-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin