Neuropeptide Y (CAS 90880-35-6)

Neuropeptide Y (NPY) is a 36-amino acid peptide that is highly conserved across species and functions primarily as a neurotransmitter in the central nervous system. It is one of the most abundant neuropeptides in the brain and is involved in a variety of physiological processes including energy balance, memory, and learning. NPY operates by binding to a family of G-protein-coupled receptors, known as Y receptors, which include several subtypes: Y1, Y2, Y4, and Y5, each mediating different physiological functions. Research applications of NPY have been extensive, focusing on its role in the regulation of food intake, circadian rhythms, and stress responses. In experimental studies, NPY has been used to examine its potent stimulatory effects on food intake, making it a key molecule in the study of obesity and metabolism. Additionally, NPY is investigated for its involvement in modulating emotional-affective processes and its high levels in stress-resilient individuals, providing insights into stress management mechanisms. Researchers also use NPY to explore its neuroprotective properties and its impact on neurogenesis and synaptic plasticity, contributing significantly to the understanding of neuronal adaptation and resilience.