neuroligin 1 Antibody (F-7): sc-365087
- neuroligin 1 Antibody (F-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 33-61 near the N-terminus of neuroligin 1 of rat origin
- recommended for detection of neuroligin 1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for neuroligin 1 Antibody (F-7) for WB applications. This reagent is now offered in a bundle with neuroligin 1 Antibody (F-7) (see ordering information below).
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Neuroligin 1 Antibody (F-7) is a mouse monoclonal IgG2b antibody that detects neuroligin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neuroligin 1 is a crucial member of the neuroligin family, which consists of plasma membrane proteins that are integral to the formation and remodeling of central nervous system synapses. Neuroligin 1 is primarily located in excitatory neuronal synaptic clefts, where neuroligin 1 plays a vital role in synaptic transmission and plasticity. Neuroligin 1 interacts with β-neurexins, specifically binding to neurexin 1β through its EF-hand domain, a process that is calcium-dependent. This interaction is essential for the recruitment of other proteins, such as PSD-95, which helps to organize synaptic structures and facilitate the clustering of ion channels and neurotransmitter receptors at the synapse. Proper functioning of neuroligin 1 is critical for maintaining synaptic integrity and communication between neurons, making neuroligin 1 a significant focus of research in understanding neurodevelopmental disorders and synaptic dysfunction. Anti-neuroligin 1 antibody (F-7) is an invaluable tool for researchers investigating these complex processes.
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neuroligin 1 Antibody (F-7) References:
- Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. | Araç, D., et al. 2007. Neuron. 56: 992-1003. PMID: 18093522
- Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. | Ko, J., et al. 2009. EMBO J. 28: 3244-55. PMID: 19730411
- Activity-dependent proteolytic cleavage of neuroligin-1. | Suzuki, K., et al. 2012. Neuron. 76: 410-22. PMID: 23083742
- Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons. | Schnell, E., et al. 2014. Front Neurosci. 8: 71. PMID: 24782702
- Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. | Fang, M., et al. 2016. Mol Neurobiol. 53: 270-284. PMID: 25428619
- Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in Rats. | Shen, H., et al. 2015. Stroke. 46: 2607-15. PMID: 26219651
- Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. | Liu, A., et al. 2016. J Cell Biol. 212: 449-63. PMID: 26880202
- Regulation of the Neuroligin-1 Gene by Clock Transcription Factors. | Hannou, L., et al. 2018. J Biol Rhythms. 33: 166-178. PMID: 29671709
- Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor. | Bizzozero, L., et al. 2022. Cells. 11: PMID: 35053395
- Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder. | Lee, IH., et al. 2023. EBioMedicine. 95: 104746. PMID: 37544204
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
neuroligin 1 Antibody (F-7) | sc-365087 | 200 µg/ml | $322.00 | |||
neuroligin 1 Antibody (F-7): m-IgG2b BP-HRP Bundle | sc-548549 | 200 µg Ab; 10 µg BP | $361.00 | |||
neuroligin 1 (F-7) Neutralizing Peptide | sc-365087 P | 100 µg/0.5 ml | $69.00 |