Neurokinin-1 Receptor Antagonist CAS: 337505-63-2
MF: C21H16ClN5OS
MW: 421.9
A high-affinity antagonist for NK1.

Neurokinin-1 Receptor Antagonist (CAS 337505-63-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 126ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: N-(3-chlorophenyl)-2-(4-phenyl-5-(4-pyridyl)(1,2,4-triazol-3-ylthio))acetamide
Application: A high-affinity antagonist for NK1
CAS Number: 337505-63-2
Molecular Weight: 421.9
Molecular Formula: C21H16ClN5OS
* Refer to Certificate of Analysis for lot specific data (including water content).

Neurokinin-1 Receptor Antagonist is a triazolyl-amide compound that acts as a high-affinity (Ki = 251 nM) antagonist for NK1, the substance P-specific neurokinin receptor. Shown to compete with substance P binding to NK1 on whole CHO cells. Exhibits similar pharmacophore features as, but is structurally distinct from, CP-96345.


References

Evers, A., and Klebe, G. 2004. Angew. Chem. Int. Ed. 43, 248.

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1122655
SMILES :
C1=CC=C(C=C1)N2C(=NN=C2SCC(=O)NC3=CC(=CC=C3)Cl)C4=CC=NC=C4

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 116ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.