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Neurokinin-1 Receptor Antagonist is a triazolyl-amide compound that acts as a high-affinity (Ki = 251 nM) antagonist for NK1, the substance P-specific neurokinin receptor. Shown to compete with substance P binding to NK1 on whole CHO cells. Exhibits similar pharmacophore features as, but is structurally distinct from, CP-96345.
Evers, A., and Klebe, G. 2004. Angew. Chem. Int. Ed. 43, 248.
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