Neurogenin 2 Antibody (2A8): sc-293430

Neurogenin 2 Antibody (2A8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Neurogenin 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Neurogenin 2 antibody (2A8) is available as a non-conjugated format. Neurogenin 2 (2A8) antibody recognizes a protein crucial for nervous system development, particularly in specifying neuronal precursors during neurogenesis. Neurogenin 2 (2A8) monoclonal antibody targets a nuclear-localized transcription factor that regulates genes essential for neuronal differentiation. Anti-Neurogenin 2 antibody (2A8) identifies a protein that interacts with transcriptional regulators and chromatin remodeling complexes, influencing neural progenitor cell fate. Precise regulation of these processes is critical for proper neuronal development and function, as dysregulation can lead to neurodevelopmental disorders. Neurogenin 2 (2A8) monoclonal antibody serves as an invaluable tool for researchers studying neural development and related pathologies across various species.

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Neurogenin 2 Antibody (2A8) References:

1. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.  |  Gradwohl, G., et al. 2000. Proc Natl Acad Sci U S A. 97: 1607-11. PMID: 10677506
2. Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.  |  Huang, HP., et al. 2000. Mol Cell Biol. 20: 3292-307. PMID: 10757813
3. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.  |  Jacquemin, P., et al. 2000. Mol Cell Biol. 20: 4445-54. PMID: 10825208
4. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.  |  Jensen, J., et al. 2000. Diabetes. 49: 163-76. PMID: 10868931
5. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.  |  Schwitzgebel, VM., et al. 2000. Development. 127: 3533-42. PMID: 10903178
6. Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate.  |  Zirlinger, M., et al. 2002. Proc Natl Acad Sci U S A. 99: 8084-9. PMID: 12060754
7. Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.  |  Andersson, E., et al. 2006. Development. 133: 507-16. PMID: 16396906
8. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury.  |  Perrin, FE., et al. 2010. PLoS One. 5: e15914. PMID: 21209909
9. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.  |  Ben-Arie, N., et al. 1996. Hum Mol Genet. 5: 1207-16. PMID: 8872459
10. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively.  |  Tamimi, RM., et al. 1997. Genomics. 40: 355-7. PMID: 9119405
11. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.  |  Ma, Q., et al. 1998. Neuron. 20: 469-82. PMID: 9539122
12. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.  |  Fode, C., et al. 1998. Neuron. 20: 483-94. PMID: 9539123