Neurexophilin-3 Antibody (B-11): sc-393156
- Neurexophilin-3 Antibody (B-11) is a mouse monoclonal IgG2a κ Neurexophilin-3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 175-202 within an internal region of Neurexophilin-3 of human origin
- Neurexophilin-3 Antibody (B-11) is recommended for detection of Neurexophilin-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-Neurexophilin-3 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Neurexophilin-3 Antibody (B-11) for WB applications. These reagents are now offered in bundles with Neurexophilin-3 Antibody (B-11) (see ordering information below).
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Neurexophilin-3 Antibody (B-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Neurexophilin-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Neurexophilin-3 antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neurexophilin-3, also known as NPH3 or NXPH3, is a member of the Neurexophilin family, which consists of neuropeptide-like glycoproteins that undergo proteolytic processing after synthesis. These proteins are primarily secreted and play a crucial role in neuronal signaling by binding to target proteins, such as neurexin Iα, which is vital for the adhesion between dendrites and axons, thereby facilitating proper neurotransmitter release. Neurexophilin-3 expression is particularly high in the brain, highlighting its importance in central nervous system function. Neurexophilin-3 is involved in various neurobiological processes, and dysregulation may contribute to neurological disorders. Understanding Neurexophilin-3 interactions and functions is essential for elucidating its role in synaptic transmission and potential implications in neuropsychiatric conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Neurexophilin-3 Antibody (B-11) References:
- Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. | Clarris, HJ., et al. 2002. Int J Dev Biol. 46: 649-52. PMID: 12141453
- Induction of GABAergic postsynaptic differentiation by alpha-neurexins. | Kang, Y., et al. 2008. J Biol Chem. 283: 2323-34. PMID: 18006501
- Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. | Nussbaum, J., et al. 2008. Hum Mol Genet. 17: 1569-77. PMID: 18270208
- Structure and evolution of neurexophilin. | Petrenko, AG., et al. 1996. J Neurosci. 16: 4360-9. PMID: 8699246
- Neurexophilins form a conserved family of neuropeptide-like glycoproteins. | Missler, M. and Südhof, TC. 1998. J Neurosci. 18: 3630-8. PMID: 9570794
- Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. | Missler, M., et al. 1998. J Biol Chem. 273: 34716-23. PMID: 9856994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neurexophilin-3 Antibody (B-11) | sc-393156 | 200 µg/ml | $316.00 | |||
Neurexophilin-3 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-523827 | 200 µg Ab, 40 µg BP | $354.00 | |||
Neurexophilin-3 Antibody (B-11): m-IgG2a BP-HRP Bundle | sc-546169 | 200 µg Ab; 10 µg BP | $354.00 | |||
Neurexophilin-3 Antibody (B-11) AC | sc-393156 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Neurexophilin-3 Antibody (B-11) HRP | sc-393156 HRP | 200 µg/ml | $316.00 | |||
Neurexophilin-3 Antibody (B-11) FITC | sc-393156 FITC | 200 µg/ml | $330.00 | |||
Neurexophilin-3 Antibody (B-11) PE | sc-393156 PE | 200 µg/ml | $343.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 488 | sc-393156 AF488 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 546 | sc-393156 AF546 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 594 | sc-393156 AF594 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 647 | sc-393156 AF647 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 680 | sc-393156 AF680 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 Antibody (B-11) Alexa Fluor® 790 | sc-393156 AF790 | 200 µg/ml | $357.00 | |||
Neurexophilin-3 (B-11) Neutralizing Peptide | sc-393156 P | 100 µg/0.5 ml | $68.00 |