Neuregulin-1/NRG1 Antibody (k1G13): sc-135811
- Neuregulin-1/NRG1 Antibody (k1G13) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against a recombinant protein corresponding to amino acids 20-241 of Neuregulin-1 isoform HRG-β3 of human origin
- recommended for detection of Neuregulin-1 of human origin by WB, IP and ELISA
- See Neuregulin-1/NRG1 (E-12): sc-393006 for Neuregulin-1/NRG1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Neuregulin-1/NRG1 Antibody (k1G13). This work is in progress.
QUICK LINKS
SEE ALSO...
Neuregulin-1 Antibody (k1G13) is a mouse monoclonal IgG1 antibody that detects Neuregulin-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Neuregulin-1 plays a crucial role in the development and function of the nervous system, particularly in the regulation of cell migration and differentiation of neural crest and Schwann cells. Neuregulin-1 is essential for the formation of neuromuscular junctions, where anti-Neuregulin-1 antibody (k1G13) detects upregulation of acetylcholine receptors at muscle fibers, facilitating effective communication between nerves and muscles. Additionally, Neuregulin-1 is involved in various signaling pathways that influence synaptic plasticity and has been implicated in neurodevelopmental disorders, including schizophrenia. The diverse isoforms of Neuregulin-1, each with unique structural features and glycosylation patterns, contribute to functional versatility and tissue-specific roles, making Neuregulin-1 monoclonal antibody (k1G13) valuable for research in neurobiology and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Neuregulin-1/NRG1 Antibody (k1G13) References:
- Acute cardiac effects of neuregulin-1/ErbB signalling. | Rochais, F. and Fischmeister, R. 2010. Cardiovasc Res. 88: 393-4. PMID: 20926427
- Neuregulin-1 as a potentially novel biomarker in acute respiratory distress syndrome. | Checkley, W. 2013. Eur Respir J. 41: 259-61. PMID: 23370800
- The roles of neuregulin-1 in cardiac development, homeostasis, and disease. | Rupert, CE. and Coulombe, KL. 2015. Biomark Insights. 10: 1-9. PMID: 25922571
- Neuregulin-1 accelerates corneal epithelial wound healing. | Jeong, WY., et al. 2017. Growth Factors. 35: 225-233. PMID: 29458290
- Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair. | Kataria, H., et al. 2019. Prog Neurobiol. 180: 101643. PMID: 31229498
- Neuregulin‑1: An underlying protective force of cardiac dysfunction in sepsis (Review). | Kang, W., et al. 2020. Mol Med Rep. 21: 2311-2320. PMID: 32236630
- Neuregulin-1, a potential therapeutic target for cardiac repair. | Wang, Y., et al. 2022. Front Pharmacol. 13: 945206. PMID: 36120374
- Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory. | Lu, Y., et al. 2023. Neuron. 111: 1684. PMID: 37201503
- Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer. | Adashek, JJ., et al. 2024. BMC Med. 22: 74. PMID: 38369520
- Neuregulin-1 reduces Doxorubicin-induced cardiotoxicity by upregulating YAP to inhibit senescence. | Shi, H., et al. 2024. Int Immunopharmacol. 143: 113278. PMID: 39405937
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neuregulin-1/NRG1 Antibody (k1G13) | sc-135811 | 50 µg/0.5 ml | $322.00 |