Neprilysin-2 Antibody (2D2H5): sc-517235

Neprilysin-2 Antibody (2D2H5) is a mouse monoclonal IgG1 antibody that detects Neprilysin-2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Neprilysin-2 is a 779 amino acid single-pass type II membrane protein belonging to the peptidase M13 family of zinc-dependent metalloproteases, which are crucial for numerous physiological processes. Neprilysin-2 is predominantly expressed in the testis, with lower levels found in the brain, kidney, and heart, highlighting a potential role in reproductive biology and development. Neprilysin-2 (2D2H5) antibody aids in studying involvement in the modulation of fertilization and early embryonic development, as well as in the inactivation of endogenous messenger peptides such as enkephalins and tachykinins, which are vital for pain perception and neuropeptide signaling. Neprilysin-2′s function in regulating these processes underscores significance in maintaining homeostasis and potential implications in various diseases, including motor sensory neuropathy 2A and neuroblastoma, which are linked to genetic defects in the Neprilysin-2 locus. Three isoforms of Neprilysin-2 exist due to alternative splicing, further diversifying functional roles in cellular processes. Anti-Neprilysin-2 antibody (2D2H5) serves as an essential tool for researchers investigating complex roles in health and disease.