Molecular structure of Neotame, CAS Number: 165450-17-9
Neotame (CAS 165450-17-9)
Application:
Neotame is a non-nutritive sweetener and an alkylated dipeptide
CAS Number:
165450-17-9
Purity:
≥98%
Molecular Weight:
378.46
Molecular Formula:
C20H30N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Neotame is a synthetic sweetener structurally similar to aspartame, yet significantly sweeter—approximately 7,000 to 13,000 times sweeter than sucrose. This high-intensity sweetener features the addition of a 3,3-dimethylbutyl group to the dipeptide derived from aspartic acid and phenylalanine. This modification not only enhances the sweetness of Neotame but also contributes to its thermal stability. The molecular structure of Neotame allows it to efficiently activate sweet taste receptors, providing a sugar-like sweetness without the calories. Its attributes are particularly useful in studies focused on understanding sweetness perception mechanisms and developing alternatives to traditional sweeteners.
Neotame (CAS 165450-17-9) References
- Neotame anhydrate polymorphs I: preparation and characterization. | Doug, Z., et al. 2002. Pharm Res. 19: 330-6. PMID: 11934241
- Artificial sweeteners--do they bear a carcinogenic risk? | Weihrauch, MR. and Diehl, V. 2004. Ann Oncol. 15: 1460-5. PMID: 15367404
- Determination of neotame in beverages, cakes and preserved fruits by column-switching high-performance liquid chromatography. | Yang, D. and Chen, B. 2010. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 27: 1221-5. PMID: 20526922
- Artificial sweeteners - a review. | Chattopadhyay, S., et al. 2014. J Food Sci Technol. 51: 611-21. PMID: 24741154
- Artificial sweeteners: safe or unsafe? | Qurrat-ul-Ain,. and Khan, SA. 2015. J Pak Med Assoc. 65: 225-7. PMID: 25842566
- Stability of aspartame and neotame in pasteurized and in-bottle sterilized flavoured milk. | Kumari, A., et al. 2016. Food Chem. 196: 533-8. PMID: 26593524
- Artificial sweeteners as a sugar substitute: Are they really safe? | Sharma, A., et al. 2016. Indian J Pharmacol. 48: 237-40. PMID: 27298490
- The role of artificial and natural sweeteners in reducing the consumption of table sugar: A narrative review. | Mooradian, AD., et al. 2017. Clin Nutr ESPEN. 18: 1-8. PMID: 29132732
- Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. | Chi, L., et al. 2018. Molecules. 23: PMID: 29425148
- Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. | Ruiz-Ojeda, FJ., et al. 2019. Adv Nutr. 10: S31-S48. PMID: 30721958
- Charge-transfer interaction of aspartame and neotame with several π-acceptors: Stoichiometric data. | Adam, AMA., et al. 2021. Data Brief. 36: 107092. PMID: 34026986
- The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review. | Wilk, K., et al. 2022. Nutrients. 14: PMID: 35334918
- Determination of neotame in various foods by high-performance liquid chromatography coupled with ultraviolet and mass spectrometric detection. | Zhu, K., et al. 2023. Food Chem. 416: 135863. PMID: 36898340
Activator of:
T1R3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neotame, 100 mg | sc-215554 | 100 mg | $80.00 | |||
Neotame, 500 mg | sc-215554A | 500 mg | $250.00 |