Date published: 2025-12-5

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Neostigmine Methyl Sulfate (CAS 51-60-5)

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Alternate Names:
3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzaminium bromide
Application:
Neostigmine Methyl Sulfate is a competitive inhibitor of acetylcholinesterase
CAS Number:
51-60-5
Molecular Weight:
334.39
Molecular Formula:
C12H19N2O2•CH3SO4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Neostigmine Methyl Sulfate is a chemical compound that functions as a reversible acetylcholinesterase inhibitor. It acts by binding to the active site of the enzyme, preventing the hydrolysis of acetylcholine and leading to an accumulation of the neurotransmitter at cholinergic synapses. This accumulation results in prolonged stimulation of the postsynaptic receptors, leading to enhanced cholinergic activity. Neostigmine Methyl Sulfate′s mode of action involves increasing the concentration of acetylcholine at the neuromuscular junction, which ultimately leads to improved muscle contraction and enhanced neuromuscular transmission. Neostigmine Methyl Sulfate′s function in experiments involves its ability to modulate cholinergic neurotransmission, making it useful for studying the role of acetylcholine in various physiological processes. Its mechanism of action at the molecular level allows for the investigation of cholinergic signaling pathways and the development of a deeper understanding of neurotransmission.


Neostigmine Methyl Sulfate (CAS 51-60-5) References

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  2. Breaking Down Myasthenic Crisis.  |  Wijdicks, EFM. 2020. Neurocrit Care. 32: 875-879. PMID: 31981022
  3. Ultrasonographic evaluation of the effects of the administration of neostigmine and metoclopramide on duodenal, cecal, and colonic contractility in Arabian horses: A comparative study.  |  Beder, NA., et al. 2020. Vet World. 13: 2447-2451. PMID: 33363340
  4. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice.  |  Polichnowski, AJ., et al. 2021. Am J Physiol Regul Integr Comp Physiol. 320: R871-R884. PMID: 33851543
  5. Uterus transplantation in a sheep model: novel surgical technique with long-term survival and uterus vitality. First case series in Argentina.  |  Maraschio, MA., et al. 2021. JBRA Assist Reprod. 25: 557-562. PMID: 34463443
  6. Effects of Natural Products on Neuromuscular Junction.  |  Akkol, EK., et al. 2022. Curr Neuropharmacol. 20: 594-610. PMID: 34561984
  7. Factors affecting improvement of neurologic status evaluated by Quantitative Myasthenia Gravis Score for patients with thymomatous myasthenia gravis after extended thymectomy.  |  Haoshuai, Z., et al. 2021. J Transl Med. 19: 413. PMID: 34600541
  8. Efficacy and Safety of Neostigmine Adjunctive Therapy in Patients With Sepsis or Septic Shock: A Randomized Controlled Trial.  |  El-Tamalawy, MM., et al. 2022. Front Pharmacol. 13: 855764. PMID: 35330830
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  12. Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules.  |  Dimiza, F., et al. 2023. Int J Mol Sci. 24: PMID: 37047364
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Neostigmine Methyl Sulfate, 1 g

sc-219348
1 g
$59.00

Neostigmine Methyl Sulfate, 5 g

sc-219348A
5 g
$165.00

Neostigmine Methyl Sulfate, 25 g

sc-219348B
25 g
$520.00