Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE. This allows acetylcholine to remain within the synapse and stimulate AChR. It is used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants.
Tatsuta M, Iishi H, Baba M, Taniguchi H. Int J Cancer. 51:767-71 (1992). Klamt JG, Dos Reis MP, Barbier neto J, Prado WA. Pain. 66:389-91 (1996).
Soluble in water (61 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMSO (<1 mg/ml at 25° C).
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