Neostigmine Bromide CAS: 114-80-7
MF: C12H19N2O2•Br
MW: 303.20
An acetylcholine esterase inhibitor.

Neostigmine Bromide (CAS 114-80-7)

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Alternate Names: Eustigmin bromide; Neoserine bromide
Application: Neostigmine Bromide is an acetylcholine esterase inhibitor
CAS Number: 114-80-7
Purity: ≥98%
Molecular Weight: 303.20
Molecular Formula: C12H19N2O2•Br
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE. This allows acetylcholine to remain within the synapse and stimulate AChR. It is used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants.


References

Tatsuta M, Iishi H, Baba M, Taniguchi H. Int J Cancer. 51:767-71 (1992). Klamt JG, Dos Reis MP, Barbier neto J, Prado WA. Pain. 66:389-91 (1996).

Physical State :
Solid
Solubility :
Soluble in water (61 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMSO (<1 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
175-177° C (lit.)
IC50 :
AChE: IC50 = 0.04 nM (human)
Ki Data :
Acetylcholinesterase: Ki= 1 µM (electrophorus electricus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BR3150000
PubChem CID :
8246
Merck Index :
14: 6464
MDL Number :
MFCD00011795
EC Number :
204-054-8
SMILES :
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]

Download SDS (MSDS)

Certificate of Analysis

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Neostigmine Bromide (CAS 114-80-7)  Product Citations

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PMID: # 30464444  Int J Chron Obstruct Pulmon Dis. 3611-3624.

Citations 1 to 1 of 1 total
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