Neostigmine Bromide (CAS 114-80-7)
Alternate Names:
Eustigmin bromide; Neoserine bromide
Application:
Neostigmine Bromide is an acetylcholine esterase inhibitor
CAS Number:
114-80-7
Purity:
≥98%
Molecular Weight:
303.20
Molecular Formula:
C12H19N2O2•Br
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE. This allows acetylcholine to remain within the synapse and stimulate AChR. It is used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants.
References
Tatsuta M, Iishi H, Baba M, Taniguchi H. Int J Cancer. 51:767-71 (1992). Klamt JG, Dos Reis MP, Barbier neto J, Prado WA. Pain. 66:389-91 (1996).
Physical State
:
Solid
Solubility
:
Soluble in water (61 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMSO (<1 mg/ml at 25° C).
Storage
:
Store at room temperature
Melting Point
:
175-177° C (lit.)
IC50
:
AChE: IC50 = 0.04 nM (human)
Ki Data
:
Acetylcholinesterase: Ki= 1 µM (electrophorus electricus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany
:
3
RTECS
:
BR3150000
PubChem CID
:
8246
Merck Index
:
14: 6464
MDL Number
:
MFCD00011795
EC Number
:
204-054-8
SMILES
:
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents