Molecular structure of (+)-Neopterin, CAS Number: 2009-64-5
(+)-Neopterin (CAS 2009-64-5)
Alternate Names:
D-erythro-Neopterin
Application:
(+)-Neopterin is a biochemical indicator for cellular proliferation
CAS Number:
2009-64-5
Purity:
≥98%
Molecular Weight:
253.22
Molecular Formula:
C9H11N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(+)-Neopterin is a pyrazino-pyrimidine compound derived from GTP that represents an intermediate product in the synthetic pathway of biopterin and is an essential cofactor in neurotransmitter synthesis. (+)-Neopterin is released from macrophages upon immune stimulation with interferon-γ from activated T cells. It is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation, immune response, and oxidative stress. Elevated levels of (+)-Neopterin are correlated to immune system activation, malignant disease, allograft rejection, and viral infections. Additionally, (+)-Neopterin serves as a cofactor for pterin in biological systems.
(+)-Neopterin (CAS 2009-64-5) References
- Increased neopterin levels in brains of patients with human immunodeficiency virus type 1 infection. | Shaskan, EG., et al. 1992. J Neurochem. 59: 1541-6. PMID: 1328524
- Distinct distributions of D-erythro-neopterin in arteries and veins and its recovery by an enterohepatic circulation. | Weiss, G., et al. 1992. Biol Chem Hoppe Seyler. 373: 289-94. PMID: 1627268
- Neopterin and viral infections: diagnostic potential in virally induced liver disease. | Reibnegger, G., et al. 1989. Biomed Pharmacother. 43: 287-93. PMID: 2676001
- D-erythro-neopterin plasma levels in intensive care patients with and without septic complications. | Strohmaier, W., et al. 1987. Crit Care Med. 15: 757-60. PMID: 3497012
- Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. | Huber, C., et al. 1983. J Immunol. 130: 1047-50. PMID: 6296230
- Raised serum neopterin levels and imbalances of T-lymphocyte subsets in viral diseases, acquired immune deficiency and related lymphadenopathy syndromes. | Kern, P., et al. 1984. Biomed Pharmacother. 38: 407-11. PMID: 6335407
- [Neopterin, a new biochemical marker for clinical assessment of cell-mediated immune response]. | Huber, C., et al. 1984. Klin Wochenschr. 62: 103-13. PMID: 6608626
- Separation of unconjugated pteridines by high-pressure cation-exchange liquid chromatography. | Stea, B., et al. 1979. J Chromatogr. 168: 385-93. PMID: 762233
- D-erythro-neopterin biosynthesis in the methanogenic archaea Methanococcus thermophila and Methanobacterium thermoautotrophicum deltaH. | Howell, DM. and White, RH. 1997. J Bacteriol. 179: 5165-70. PMID: 9260960
Inhibitor of:
GUK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Neopterin, 10 mg | sc-202241 | 10 mg | $51.00 | |||
| US: Only available in the US | ||||||
(+)-Neopterin, 50 mg | sc-202241A | 50 mg | $204.00 | |||
| US: Only available in the US | ||||||