Date published: 2026-4-19

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Neoaureothin (CAS 28900-27-8)

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Alternate Names:
Spectabilin
Application:
Neoaureothin is a chain-extended analog of aureothin
CAS Number:
28900-27-8
Purity:
≥98%
Molecular Weight:
477.55
Molecular Formula:
C28H31NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Neoaureothin is a complex polyketide natural product, recognized for its distinctive structural features that include a spirotetronate motif intertwined with a polyene chain. This compound is biosynthesized through a series of intricate enzymatic pathways that involve polyketide synthases (PKSs), highlighting the sophisticated machinery cells possess for generating diverse molecular architectures. In research applications, neoaureothin′s mechanism of action has been a subject of interest due to its interaction with cellular processes, particularly how its structure impacts the bioactivity within microbial communities. It serves as a valuable probe for understanding the role of polyketides in ecological interactions and the evolutionary pressures that shape the production of secondary metabolites in microorganisms. By dissecting the mode of action of neoaureothin, scientists can uncover fundamental principles about molecular recognition and interaction, contributing to the broader field of chemical biology and natural product chemistry. This exploration not only enriches our knowledge of biological diversity and chemical ecology but also aids in the discovery and development of novel compounds with potential applications in various biotechnological fields.


Neoaureothin (CAS 28900-27-8) References

  1. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective.  |  Traitcheva, N., et al. 2007. Chembiochem. 8: 1841-9. PMID: 17763486
  2. CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters.  |  Weber, T., et al. 2009. J Biotechnol. 140: 13-7. PMID: 19297688
  3. The biosynthetic logic of polyketide diversity.  |  Hertweck, C. 2009. Angew Chem Int Ed Engl. 48: 4688-716. PMID: 19514004
  4. Evolution of metabolic diversity: insights from microbial polyketide synthases.  |  Jenke-Kodama, H. and Dittmann, E. 2009. Phytochemistry. 70: 1858-66. PMID: 19619887
  5. Evolution of metabolic diversity in polyketide-derived pyrones: using the non-colinear aureothin assembly line as a model system.  |  Busch, B. and Hertweck, C. 2009. Phytochemistry. 70: 1833-40. PMID: 19651421
  6. Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway.  |  Richter, M., et al. 2012. Chembiochem. 13: 2196-9. PMID: 22961965
  7. Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line.  |  Sugimoto, Y., et al. 2014. Angew Chem Int Ed Engl. 53: 1560-4. PMID: 24402879
  8. Freedom and constraint in engineered noncolinear polyketide assembly lines.  |  Sugimoto, Y., et al. 2015. Chem Biol. 22: 229-40. PMID: 25660274
  9. Polyketide Synthase Modules Redefined.  |  Keatinge-Clay, AT. 2017. Angew Chem Int Ed Engl. 56: 4658-4660. PMID: 28322495
  10. The complete genomic sequence of Streptomyces spectabilis NRRL-2792 and identification of secondary metabolite biosynthetic gene clusters.  |  Sinha, A., et al. 2019. J Ind Microbiol Biotechnol. 46: 1217-1223. PMID: 31197515
  11. Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases.  |  Peng, H., et al. 2019. Nat Commun. 10: 3918. PMID: 31477708
  12. The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo.  |  Gao, X., et al. 2019. Bioorg Chem. 93: 103311. PMID: 31586709
  13. Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin.  |  Herrmann, A., et al. 2020. Sci Rep. 10: 1326. PMID: 31992748
  14. Quorum sensing-based metabolic engineering of the precursor supply in Streptomyces coelicolor to improve heterologous production of neoaureothin.  |  Kim, DK., et al. 2023. Biotechnol Bioeng.. PMID: 37042226

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Neoaureothin, 500 µg

sc-202242
500 µg
$288.00