Nemadipine-A (CAS 54280-71-6)
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Nemadipine-A is a chemical compound widely employed in the field of neurobiology and pharmacology research, particularly in studies involving the model organism Caenorhabditis elegans. This compound is known for its ability to selectively inhibit L-type calcium channels, which are critical for proper neural function and muscle contraction. Research involving Nemadipine-A focuses on elucidating calcium signaling pathways, especially those that govern neuron and muscle physiology. Studies have explored its effects on behavior, development, and neuroplasticity, providing a deeper understanding of how calcium channel regulation can impact an organism′s overall health and function. Additionally, Nemadipine-A is used to dissect the genetic components of calcium channel-related diseases, as well as to assist in the identification of potential targets for modulating calcium channel activity.
Nemadipine-A (CAS 54280-71-6) References
- CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx. | Shtonda, B. and Avery, L. 2005. J Exp Biol. 208: 2177-90. PMID: 15914661
- A small-molecule screen in C. elegans yields a new calcium channel antagonist. | Kwok, TC., et al. 2006. Nature. 441: 91-5. PMID: 16672971
- Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. | Park, SH., et al. 2013. Biomol Ther (Seoul). 21: 29-34. PMID: 24009855
- High-throughput imaging of neuronal activity in Caenorhabditis elegans. | Larsch, J., et al. 2013. Proc Natl Acad Sci U S A. 110: E4266-73. PMID: 24145415
- Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor. | Zahratka, JA., et al. 2015. J Neurophysiol. 113: 1041-50. PMID: 25411461
- Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation. | Sun, L., et al. 2014. J Neurosci. 34: 15947-56. PMID: 25429136
- Dendrites actively restrain axon outgrowth and regeneration. | Francis, MM. and Freeman, MR. 2016. Proc Natl Acad Sci U S A. 113: 5465-6. PMID: 27147603
- Active propagation of dendritic electrical signals in C. elegans. | Shindou, T., et al. 2019. Sci Rep. 9: 3430. PMID: 30837592
- Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline. | Volpatti, JR., et al. 2020. Elife. 9: PMID: 32223895
- A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules. | Zorn, KM., et al. 2021. ACS Infect Dis. 7: 406-420. PMID: 33434015
- An Optogenetic Arrhythmia Model-Insertion of Several Catecholaminergic Polymorphic Ventricular Tachycardia Mutations Into Caenorhabditis elegans UNC-68 Disturbs Calstabin-Mediated Stabilization of the Ryanodine Receptor Homolog. | Engel, MA., et al. 2022. Front Physiol. 13: 691829. PMID: 35399287
- A repositioning screen using an FGFR2 splicing reporter reveals compounds that regulate epithelial-mesenchymal transitions and inhibit growth of prostate cancer xenografts. | Li, L., et al. 2022. Mol Ther Methods Clin Dev. 25: 147-157. PMID: 35402635
- High-Throughput In Vitro Screening Identified Nemadipine as a Novel Suppressor of Embryo Implantation. | Chen, X., et al. 2022. Int J Mol Sci. 23: PMID: 35563464
- Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway. | Debnath, A., et al. 2022. Front Neurosci. 16: 931328. PMID: 35937887
- Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. | Lee, RY., et al. 1997. EMBO J. 16: 6066-76. PMID: 9321386
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nemadipine-A, 5 mg | sc-202727 | 5 mg | $66.00 |