Nek4 Antibody (2631C1a): sc-81332

Nek4 Antibody (2631C1a) is a mouse monoclonal IgG1 antibody that detects Nek4 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Nek4 antibody (2631C1a) is available as a non-conjugated format, providing researchers with a reliable tool for studying Nek4. Nek4 protein plays a crucial role in cell cycle regulation, particularly during the transition from G2 phase to mitosis, which is essential for proper cell division and proliferation. Understanding Nek4 function is vital, as dysregulation can lead to various diseases, including cancer. In mammals, Nek4 is part of a family of NIMA-related kinases, which includes Nek1, Nek2, and Nek3, each exhibiting distinct expression patterns and functions. Notably, Nek4 expression is particularly significant in developing testicular germ cells, where Nek4 may interact with other members of the Nek family to coordinate cell cycle progression and differentiation. Nek4 monoclonal antibody (2631C1a) enables researchers to gain insights into molecular mechanisms underlying cell cycle control and potential implications in developmental biology and disease.

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Nek4 Antibody (2631C1a) References:

1. Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators.  |  Tanaka, K. and Nigg, EA. 1999. J Biol Chem. 274: 13491-7. PMID: 10224116
2. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.  |  Chen, A., et al. 1999. Gene. 234: 127-37. PMID: 10393247
3. A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.  |  Letwin, K., et al. 1992. EMBO J. 11: 3521-31. PMID: 1382974
4. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase.  |  Osmani, SA., et al. 1988. Cell. 53: 237-44. PMID: 3359487
5. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.  |  Schultz, SJ., et al. 1994. Cell Growth Differ. 5: 625-35. PMID: 7522034
6. The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes.  |  Rhee, K. and Wolgemuth, DJ. 1997. Development. 124: 2167-77. PMID: 9187143
7. Characterization of mammalian NIMA-related kinases.  |  Fry, AM. and Nigg, EA. 1997. Methods Enzymol. 283: 270-82. PMID: 9251026

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nek4 Antibody (2631C1a) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Nek4 Antibody (2631C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nek4 Antibody (2631C1a) Specifications

Alternate Product Name: Nek4

Product Clone Name: 2631C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Nek4

Epitope Species: human

Product Reactivity/Detection: Nek4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Nek4 Antibody (2631C1a): N/A