Nek11 Antibody (36JK): sc-100429

Nek11 Antibody (36JK) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Nek11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Nek11 antibody (36JK) is available as the non-conjugated format. Nek11, also known as NIMA-related kinase 11, plays a crucial role in cell cycle regulation, particularly during the S phase checkpoint, where Nek11 ensures proper DNA replication and repair. Nek11 belongs to the NIMA subfamily of kinases, which are essential for the cellular response to genotoxic stress. Nek11 is expressed at low levels in various tissues, including the trachea, lung, uterus, appendix, and cerebellum, with localization tightly regulated throughout the cell cycle; Nek11 is predominantly found in the nucleus during interphase and associates with polar microtubules during prometaphase and metaphase. Two isoforms, Nek11L and Nek11S, result from alternative splicing, highlighting the complexity of regulation and function. Using Nek11 (36JK) antibody in research can provide valuable insights into cell cycle control mechanisms and Nek11′s role in cellular responses to DNA damage.

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Nek11 Antibody (36JK) References:

1. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.  |  Noguchi, K., et al. 2002. J Biol Chem. 277: 39655-65. PMID: 12154088
2. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.  |  Belham, C., et al. 2003. J Biol Chem. 278: 34897-909. PMID: 12840024
3. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.  |  Noguchi, K., et al. 2004. J Biol Chem. 279: 32716-27. PMID: 15161910
4. Mitotic regulation by NIMA-related kinases.  |  O'regan, L., et al. 2007. Cell Div. 2: 25. PMID: 17727698
5. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase.  |  Osmani, SA., et al. 1988. Cell. 53: 237-44. PMID: 3359487
6. Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans.  |  Fry, AM., et al. 1995. J Biol Chem. 270: 12899-905. PMID: 7759549

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nek11 Antibody (36JK) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Nek11 Antibody (36JK) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nek11 Antibody (36JK) Specifications

Alternate Product Name: Nek11

Product Clone Name: 36JK

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-483

Epitope Target: Nek11

Epitope Species: human

Product Reactivity/Detection: Nek11

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Nek11 Antibody (36JK): N/A