Nek10 Antibody (97.1): sc-100434

Nek10 Antibody (97.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Nek10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Nek10 antibody (97.1) is available as the non-conjugated format. Nek10, also known as NIMA (never in mitosis gene a)-related kinase 10, is a 712 amino acid protein that plays a crucial role in cell cycle regulation, particularly in mitosis transition. Nek10 belongs to the NIMA subfamily of kinases, which are essential for responding to genotoxic stress and facilitating DNA replication. Nek10 is predominantly expressed in the brain and may contain a 14-3-3 interaction motif at its C-terminus, significant for regulatory functions and protein interactions. Nek10 gene is located on chromosome 3, a region implicated in addiction susceptibility, highlighting potential impact on neurological processes. Alternative splicing of Nek10 gene results in three distinct isoforms, which may have different functional roles in cellular processes.

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Nek10 Antibody (97.1) References:

1. Genomic analysis of the eukaryotic protein kinase superfamily: a perspective.  |  Hanks, SK. 2003. Genome Biol. 4: 111. PMID: 12734000
2. The mouse kinome: discovery and comparative genomics of all mouse protein kinases.  |  Caenepeel, S., et al. 2004. Proc Natl Acad Sci U S A. 101: 11707-12. PMID: 15289607
3. Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.  |  Roig, J., et al. 2005. Mol Biol Cell. 16: 4827-40. PMID: 16079175
4. Characterization of a poplar NIMA-related kinase PNek1 and its potential role in meristematic activity.  |  Cloutier, M., et al. 2005. FEBS Lett. 579: 4659-65. PMID: 16098516
5. Structure and regulation of the human Nek2 centrosomal kinase.  |  Rellos, P., et al. 2007. J Biol Chem. 282: 6833-42. PMID: 17197699
6. Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples.  |  Ishiguro, H., et al. 2007. Addiction. 102: 1320-5. PMID: 17624982
7. Mitotic regulation by NIMA-related kinases.  |  O'regan, L., et al. 2007. Cell Div. 2: 25. PMID: 17727698
8. Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases.  |  Parker, JD., et al. 2007. PLoS One. 2: e1076. PMID: 17957258

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nek10 Antibody (97.1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Nek10 Antibody (97.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nek10 Antibody (97.1) Specifications

Alternate Product Name: Nek10

Product Clone Name: 97.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 211-301

Epitope Target: Nek10

Epitope Species: human

Product Reactivity/Detection: Nek10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Nek10 Antibody (97.1): N/A