NEIL2 Antibody (2626C2a): sc-81566

NEIL2 Antibody (2626C2a) is a mouse monoclonal IgG1 antibody that detects NEIL2 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NEIL2 antibody (2626C2a) is available as a non-conjugated format and plays a crucial role in the cellular response to oxidative DNA damage. NEIL2 (2626C2a) antibody recognizes NEIL2 protein, part of the FPG family of proteins, which functions as a DNA glycosylase, specifically recognizing and excising damaged bases from DNA, thereby facilitating repair process and maintaining genomic stability. This function helps prevent mutations that could lead to various diseases, including cancer. NEIL2 is predominantly expressed in tissues such as testis, heart, skeletal muscle, placenta, brain, kidney, and liver, highlighting significance in both reproductive and metabolic processes. Anti-NEIL2 antibody (2626C2a) can help researchers study NEIL2′s interaction with other proteins involved in DNA repair pathways, underscoring essential role in cellular health and integrity. NEIL2 (2626C2a) monoclonal antibody enables valuable insights into mechanisms of DNA repair and implications of oxidative stress in various biological contexts.

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NEIL2 Antibody (2626C2a) References:

1. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.  |  Hazra, TK., et al. 2002. J Biol Chem. 277: 30417-20. PMID: 12097317
2. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.  |  Dou, H., et al. 2003. J Biol Chem. 278: 49679-84. PMID: 14522990
3. Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.  |  Bhakat, KK., et al. 2004. Nucleic Acids Res. 32: 3033-9. PMID: 15175427
4. Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein.  |  Das, A., et al. 2004. J Biol Chem. 279: 47132-8. PMID: 15339932
5. Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.  |  Hailer, MK., et al. 2005. DNA Repair (Amst). 4: 41-50. PMID: 15533836
6. The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro.  |  Conlon, KA., et al. 2005. DNA Repair (Amst). 4: 419-31. PMID: 15725623

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NEIL2 Antibody (2626C2a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NEIL2 Antibody (2626C2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NEIL2 Antibody (2626C2a) Specifications

Alternate Product Name: NEIL2

Product Clone Name: 2626C2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: NEIL2

Epitope Species: human

Product Reactivity/Detection: NEIL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NEIL2 Antibody (2626C2a): N/A