Molecular structure of Nefiracetam, CAS Number: 77191-36-7
Nefiracetam (CAS 77191-36-7)
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Alternate Names:
N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; Translon
Application:
Nefiracetam is activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems
CAS Number:
77191-36-7
Purity:
≥99%
Molecular Weight:
246.3
Molecular Formula:
C14H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nefiracetam functions as a cognitive enhancer in experimental applications. It is a positive allosteric modulator of the AMPA and kainate receptors. This mechanism of action results in improved synaptic plasticity and enhanced memory formation. Nefiracetam also exhibits neuroprotective properties by promoting the release of neurotrophic factors and reducing oxidative stress. Nefiracetam′s mechanism of action involves enhancing neuronal communication and promoting neuroplasticity
Nefiracetam (CAS 77191-36-7) References
- [Facilitatory actions of the cognitive enhancer nefiracetam on neuronal Ca2+ channels and nicotinic ACh receptors: their intracellular signal transduction pathways]. | Yoshii, M., et al. 1998. Nihon Yakurigaku Zasshi. 112 Suppl 1: 41P-43P. PMID: 10190131
- Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action. | Nomura, T. and Nishizaki, T. 2000. Brain Res. 870: 157-62. PMID: 10869513
- Nefiracetam improves Morris water maze performance following traumatic brain injury in rats. | DeFord, SM., et al. 2001. Pharmacol Biochem Behav. 69: 611-6. PMID: 11509223
- Nefiracetam. Daiichi Seiyaku. | Crespi, F. 2002. Curr Opin Investig Drugs. 3: 788-93. PMID: 12090554
- Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats. | Yan, Y., et al. 2004. Ann N Y Acad Sci. 1025: 274-8. PMID: 15542727
- Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor. | Moriguchi, S., et al. 2007. Mol Pharmacol. 71: 580-7. PMID: 17095583
- Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. | Moriguchi, S., et al. 2009. Neuroscience. 160: 484-91. PMID: 19272425
- Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. | Moriguchi, S., et al. 2009. J Neurochem. 110: 170-81. PMID: 19457128
- Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. | Malykh, AG. and Sadaie, MR. 2010. Drugs. 70: 287-312. PMID: 20166767
- Molecular dynamics study-based mechanism of nefiracetam-induced NMDA receptor potentiation. | Omotuyi, OI. and Ueda, H. 2015. Comput Biol Chem. 55: 14-22. PMID: 25659913
- Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach. | Buol, X., et al. 2020. Pharmaceutics. 12: PMID: 32660115
- Nefiracetam, a novel cognition-enhancing agent. An introductory overview. | Tanaka, M., et al. 1994. Arzneimittelforschung. 44: 193-4. PMID: 8018089
- Effects of nefiracetam on amnesia animal models with neuronal dysfunctions. | Hiramatsu, M., et al. 1997. Behav Brain Res. 83: 107-15. PMID: 9062668
Inhibitor of:
C2orf37, FCHO1, Gat1, Iba1, and NFATc2IP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nefiracetam, 100 mg | sc-205766 | 100 mg | $128.00 | |||
Nefiracetam, 250 mg | sc-205766A | 250 mg | $143.00 |