Molecular structure of Nefazodone hydrochloride, CAS Number: 82752-99-6
Nefazodone hydrochloride (CAS 82752-99-6)
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Alternate Names:
Serzone; Dutonin; Menfazona; Rulivan; Reseril; Nefazodone Hcl
Application:
Nefazodone hydrochloride is a SR-2A antagonist
CAS Number:
82752-99-6
Purity:
≥98%
Molecular Weight:
506.47
Molecular Formula:
C25H32ClN5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential.
Nefazodone hydrochloride (CAS 82752-99-6) References
- Effects of nefazodone on the immune system of mice. | Freire-Garabal, M., et al. 2000. Eur Neuropsychopharmacol. 10: 255-64. PMID: 10871707
- LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the antidepressant, nefazodone. | Pullar, IA., et al. 2000. Eur J Pharmacol. 407: 39-46. PMID: 11050288
- LC determination and purity evaluation of nefazodone HCl in bulk drug and pharmaceutical formulations. | Sreenivas Rao, D., et al. 2001. J Pharm Biomed Anal. 26: 629-36. PMID: 11516915
- Effects of nefazodone on voluntary ethanol consumption induced by isolation stress in young and aged rats. | Núñez, MJ., et al. 2002. Pharmacol Biochem Behav. 73: 689-96. PMID: 12151045
- Pharmacokinetics of nefazodone following multiple escalating oral doses in the dog. | Shukla, UA., et al. 1992. Eur J Drug Metab Pharmacokinet. 17: 309-18. PMID: 1301361
- Rapid and simple methods for quantitative analysis of some antidepressant in pharmaceutical formulations by using first derivative spectrophotometry and HPLC. | Erk, N. 2003. Farmaco. 58: 1209-16. PMID: 14630230
- Evaluation of nefazodone self-administration in rhesus monkeys. | Gold, LH. and Balster, RL. 1991. Drug Alcohol Depend. 28: 241-7. PMID: 1752199
- Nefazodone: preclinical pharmacology of a new antidepressant. | Eison, AS., et al. 1990. Psychopharmacol Bull. 26: 311-5. PMID: 2274630
- Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells. | Ren, Z., et al. 2016. Toxicol Sci. 154: 368-380. PMID: 27613715
- Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. | Davis, R., et al. 1997. Drugs. 53: 608-36. PMID: 9098663
Inhibitor of:
SR-2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nefazodone hydrochloride, 1 g | sc-203156 | 1 g | $117.00 | |||
Nefazodone hydrochloride, 5 g | sc-203156A | 5 g | $407.00 |