Nefazodone hydrochloride CAS: 82752-99-6
MF: C25H32ClN5O2•HCl
MW: 506.47
A SR-2A antagonist.

Nefazodone hydrochloride (CAS 82752-99-6)

Nefazodone hydrochloride | CAS 82752-99-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Serzone; Dutonin; Menfazona; Rulivan; Reseril; Nefazodone Hcl
Application: Nefazodone hydrochloride is a SR-2A antagonist
CAS Number: 82752-99-6
Purity: ≥98%
Molecular Weight: 506.47
Molecular Formula: C25H32ClN5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nefazodone hydrochloride is a SR-2A antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Nefazodone hydrochloride displays no activity at SR-1B and SR-1D. It is active in models predictive of antidepressant potential.


References

1. Eison, A.S. et al. 1990. Psychopharmacol Bull. 26(3): 311-315. PMID: 2274630

2. Davis, R. et al. 1997. Drugs. 53(4): 608-636. PMID: 9098663

3. Pullar, I.A. et al. 2000. Eur. J. Pharmacol. 407(1-2): 39-46. PMID: 11050288

Physical State :
Solid
Solubility :
Soluble in DMSO (≥ 10 mg/ml), methanol, ethanol (10 mM), and 1 eq. HCl (10 mM). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
182-188° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Serotonin uptake : IC50 = 290 nM; Norepinephrine uptake: IC50 = 300 nM
Ki Data :
α1-adrenoceptors: Ki= 5.5 nM; [3H] ketanserin binding: Ki= 7.1 nM (rat cortex); α2-adrenoceptors: Ki= 84 nM; SERT: Ki= 220 nM (rat); NET: Ki= 555 nM (rat)
pK Values :
pKa: 6.64 (25° C)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
Merck Index :
14: 6438
MDL Number :
MFCD00935760
Beilstein Registry :
4636943
SMILES :
CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl

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Certificate of Analysis

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Is Nefazodone available for sale to patients? I have been on it 26 years and now I’m very sick since I can’t get it right now. Please help. 

Asked by: Jolomi
Thank you for your questions . Santa Cruz Biotechnology products are sold for research or laboratory use only and are not to be administered to humans or used for medical diagnostics.
Answered by: Blake J
Date published: 2021-08-02
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Rated 5 out of 5 by from Pullar et al Pullar et al. (PubMed ID 11050288) showed that the antidepressant, nefazodone hydrochloride, inhibited 5-HT absorption into rat cortical synaptosomes and enhanced potassium-induced 5-HT secretion from guinea pig cortical slices via 5-HT (2A) antagonism. -SCBT Publication Review
Date published: 2015-02-03
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