Nectin 1 Antibody (F-10): sc-271063

Nectin 1 Antibody (F-10) is a mouse monoclonal IgM antibody that detects Nectin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nectin 1 is a crucial member of the immunoglobulin superfamily, functioning as a homophilic cell adhesion molecule that plays a significant role in cellular interactions and signaling. Nectin 1 is predominantly expressed in the brain and exists in two isoforms, Nectin 1α and Nectin 1β/HIgR, which arise from alternative splicing. The cytoplasmic region of Nectin 1α contains a conserved C-terminal motif that is essential for interaction with the PDZ domain of afadin, a protein that links Nectin 1 to the actin cytoskeleton, thereby facilitating the structural integrity of adherens junctions. This interaction is vital for maintaining cell adhesion and tissue architecture, as well as for the entry of herpes simplex virus types 1 and 2 into host cells, highlighting Nectin 1′s importance in both normal physiology and viral pathogenesis. The binding of viral glycoprotein D to Nectin 1 is a critical step in the infection process, underscoring Nectin 1′s role in mediating viral entry and potential as a target for therapeutic intervention. Anti-Nectin 1 antibody (F-10) is an invaluable tool for researchers studying cell adhesion mechanisms, viral entry pathways, and molecular interactions that underpin cellular architecture.

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Nectin 1 Antibody (F-10) References:

1. Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions.  |  Struyf, F., et al. 2002. J Virol. 76: 12940-50. PMID: 12438620
2. Nectin-1 expression in the normal and neoplastic human uterine cervix.  |  Guzman, G., et al. 2006. Arch Pathol Lab Med. 130: 1193-5. PMID: 16879022
3. Expression of nectin-1 in normal and herpes simplex virus type 1-infected murine brain.  |  Shukla, D., et al. 2006. Appl Immunohistochem Mol Morphol. 14: 341-7. PMID: 16932027
4. Nectin-1 expression by squamous cell carcinoma is a predictor of herpes oncolytic sensitivity.  |  Yu, Z., et al. 2007. Mol Ther. 15: 103-13. PMID: 17164781
5. Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts.  |  Petermann, P., et al. 2015. J Virol. 89: 9407-16. PMID: 26136572
6. Role of Nectin-1/c-Src Signaling in the Analgesic Effect of GDNF on a Rat Model of Chronic Constrictive Injury.  |  Gao, YY., et al. 2016. J Mol Neurosci. 60: 258-66. PMID: 27394444
7. Cbl E3 Ligase Mediates the Removal of Nectin-1 from the Surface of Herpes Simplex Virus 1-Infected Cells.  |  Deschamps, T., et al. 2017. J Virol. 91: PMID: 28381567
8. Invasion of Herpes Simplex Virus 1 into Murine Dermis: Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors during Aging.  |  Wirtz, L., et al. 2020. J Virol. 94: PMID: 31826998
9. Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.  |  Yue, D., et al. 2020. Sci Adv. 6: eaba5147. PMID: 32426511
10. Corrigendum: High expression of nectin-1 indicates a poor prognosis and promotes metastasis in hepatocellular carcinoma.  |  Wang, X., et al. 2023. Front Oncol. 13: 1134139. PMID: 37025598

The preferred Nectin 1 antibody is Nectin 1 Antibody (CK6): sc-21722.