Necrox-5 methanesulfonate (CAS 1383718-29-3)
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Necrox-5 methanesulfonate is an innovative synthetic compound developed by scientists to investigate the intricacies of necrosis through laboratory experiments. Necrosis, a form of cell death, manifests when cells are subjected to external factors like toxins, radiation, or physical trauma, resulting in their damage or demise. Serving as a novel necrosis-inducing compound, Necrox-5 methanesulfonate has been employed extensively to scrutinize the biochemical and physiological consequences of necrosis in laboratory applications. Mechanistically, Necrox-5 methanesulfonate triggers necrosis by disrupting the integrity of the cell membrane. This disruption induces an increase in cell membrane permeability, allowing the entry of ions and molecules into the cell. Consequently, this influx of ions and molecules disrupts the normal cellular functioning, ultimately leading to cell death.
Necrox-5 methanesulfonate (CAS 1383718-29-3) References
- CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway. | Chen, MS., et al. 2017. Oncotarget. 8: 114588-114602. PMID: 29383104
- Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. | Fujiki, K., et al. 2019. Cell Death Differ. 26: 2371-2385. PMID: 30804470
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrox-5 methanesulfonate, 1 mg | sc-391056 | 1 mg | $156.00 | |||
Necrox-5 methanesulfonate, 5 mg | sc-391056A | 5 mg | $406.00 |