Necrox-2
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Necrox-2 is a chemical compound that functions as a potent inhibitor of a specific enzyme involved in cellular metabolism. It exerts its mode of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting the metabolic pathways in which it participates. Disruption leads to a cascade of downstream effects on cellular processes, making Necrox-2 a valuable for studying the intricate regulation of metabolic pathways in various experimental models. Necrox-2 allows researchers to elucidate the molecular mechanisms underlying its role in cellular metabolism. In experimental applications, Necrox-2′s mode of action at the molecular level provides valuable insights into the complex interplay of metabolic pathways and their potential implications for various physiological and pathological conditions.
Necrox-2 References
- NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. | Kim, HJ., et al. 2010. Arch Pharm Res. 33: 1813-23. PMID: 21116785
- Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection. | Lum, M. and Morona, R. 2014. Int J Med Microbiol. 304: 530-41. PMID: 24755420
- BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells. | Wang, B., et al. 2014. Toxicol Sci. 140: 393-402. PMID: 24824807
- The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity. | Li, Q., et al. 2015. Nat Commun. 6: 6183. PMID: 25630387
- Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion. | You, BR. and Park, WH. 2016. Oncol Rep. 35: 546-51. PMID: 26530353
- Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms. | Pinkerneil, M., et al. 2016. Mol Cancer Ther. 15: 299-312. PMID: 26772204
- Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines. | Pinkerneil, M., et al. 2016. Target Oncol. 11: 783-798. PMID: 27250763
- Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells. | You, BR., et al. 2017. Oncotarget. 8: 17726-17737. PMID: 28099148
- Progesterone Prevents High-Grade Serous Ovarian Cancer by Inducing Necroptosis of p53-Defective Fallopian Tube Epithelial Cells. | Wu, NY., et al. 2017. Cell Rep. 18: 2557-2565. PMID: 28297660
- Susceptibility of Mycobacterium tuberculosis-infected host cells to phospho-MLKL driven necroptosis is dependent on cell type and presence of TNFα. | Butler, RE., et al. 2017. Virulence. 8: 1820-1832. PMID: 28892415
- FasL on the surface of Tag7 (PGRP-S)-activated lymphocytes induces necroptosis in HLA-negative tumor cells with the involvement of lysosomes and mitochondria. | Sharapova, TN., et al. 2018. Biochimie. 152: 174-180. PMID: 30103900
- Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response. | Nagashima, R., et al. 2019. J Immunol. 202: 1331-1339. PMID: 30674574
- Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. | Fujiki, K., et al. 2019. Cell Death Differ. 26: 2371-2385. PMID: 30804470
- RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis. | Lee, J., et al. 2022. Mol Cells. 45: 193-201. PMID: 35289306
- Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells. | Zhang, J., et al. 2023. Cell Death Dis. 14: 238. PMID: 37015922
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrox-2, 1 mg | sc-391057 | 1 mg | $143.00 | |||
Necrox-2, 5 mg | sc-391057A | 5 mg | $491.00 |