Molecular structure of Necrosulfonamide, CAS Number: 432531-71-0
Necrosulfonamide (CAS 432531-71-0)
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Alternate Names:
N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide
CAS Number:
432531-71-0
Molecular Weight:
461.47
Molecular Formula:
C18H15N5O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. Necrosulfonamide prevents the progression of necroptotic cell death. This molecule has been useful in scientific research for understanding the molecular mechanisms of necroptosis and its role in various diseases.
Necrosulfonamide (CAS 432531-71-0) References
- Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition. | Wang, Y., et al. 2018. World Neurosurg. 114: e1186-e1191. PMID: 29614353
- Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. | Liu, J., et al. 2019. Aging (Albany NY). 11: 7830-7846. PMID: 31553952
- Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. | Majdi, A., et al. 2020. J Hepatol. 72: 627-635. PMID: 31760070
- Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity. | Jiao, J., et al. 2019. Front Pharmacol. 10: 1538. PMID: 31998134
- Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. | Duan, X., et al. 2020. Cell Death Dis. 11: 134. PMID: 32075957
- Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibition. | Zhang, QX., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 2683-2691. PMID: 32196619
- New mechanism of nerve injury in Alzheimer's disease: β-amyloid-induced neuronal pyroptosis. | Han, C., et al. 2020. J Cell Mol Med. 24: 8078-8090. PMID: 32521573
- Ameliorative Effect of Necrosulfonamide in a Rat Model of Alzheimer's Disease: Targeting Mixed Lineage Kinase Domain-like Protein-Mediated Necroptosis. | Motawi, TMK., et al. 2020. ACS Chem Neurosci. 11: 3386-3397. PMID: 32936609
- EF24 induces ferroptosis in osteosarcoma cells through HMOX1. | Lin, H., et al. 2021. Biomed Pharmacother. 136: 111202. PMID: 33453607
- Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis. | Ueda, S., et al. 2022. J Thorac Cardiovasc Surg. 163: e113-e122. PMID: 33612303
- Necrosulfonamide reverses pyroptosis-induced inhibition of proliferation and differentiation of osteoblasts through the NLRP3/caspase-1/GSDMD pathway. | Zhang, J. and Wei, K. 2021. Exp Cell Res. 405: 112648. PMID: 34119493
- Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells. | Chen, S., et al. 2022. Chem Res Toxicol. 35: 387-391. PMID: 35263988
- Necrosulfonamide improves post-resuscitation myocardial dysfunction via inhibiting pyroptosis and necroptosis in a rat model of cardiac arrest. | He, F., et al. 2022. Eur J Pharmacol. 926: 175037. PMID: 35588872
- Inhibition of IL-1β release from macrophages targeted with necrosulfonamide-loaded porous nanoparticles. | Boersma, B., et al. 2022. J Control Release. 351: 989-1002. PMID: 36202154
- Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice. | Wu, YL., et al. 2022. J Clin Transl Hepatol. 10: 1148-1154. PMID: 36381100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrosulfonamide, 1 mg | sc-477701 | 1 mg | $333.00 |