Molecular structure of Necrostatin-7, CAS Number: 351062-08-3
Necrostatin-7 (CAS 351062-08-3)
Alternate Names:
Nec-7; 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone
Application:
Necrostatin-7 is a Necroptosis inhibitor that does not inhibit RIP1 kinase
CAS Number:
351062-08-3
Purity:
≥98%
Molecular Weight:
371.41
Molecular Formula:
C16H10FN5OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Necrostatin-7 is a Necroptosis inhibitor that does not inhibit RIP1 kinase. Necroptosis is a controlled cell death process that lacks caspase involvement and exhibits morphological characteristics similar to necrosis. Necrostatin-7 stands apart from necrostatin-1, -3, -4, and -5 in both structure and biological properties. It is believed that Necrostatin-7 might target an extra regulatory molecule in this pathway, as it effectively inhibits TNF-α-induced necroptosis in FADD-deficient human Jurkat T cells, with an EC50 value of 10.6 μM.
Necrostatin-7 (CAS 351062-08-3) References
- Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. | Zheng, W., et al. 2008. Bioorg Med Chem Lett. 18: 4932-5. PMID: 18768316
- Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. | Ding, B., et al. 2016. Sci Rep. 6: 22538. PMID: 26932729
- Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. | González-Juarbe, N., et al. 2017. Cell Death Differ. 24: 917-928. PMID: 28387756
- The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity. | Tong, ZB., et al. 2018. Chem Res Toxicol. 31: 127-136. PMID: 29156121
- Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. | Holze, C., et al. 2018. Nat Immunol. 19: 130-140. PMID: 29255269
- GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress. | Gonzalez-Menendez, P., et al. 2018. Redox Biol. 17: 112-127. PMID: 29684818
- Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. | Azzouz, D., et al. 2018. Cell Death Discov. 4: 51. PMID: 29736268
- Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. | Fuji, H., et al. 2018. Biochem Biophys Res Commun. 503: 544-549. PMID: 29800570
- The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats Are Possibly Mediated by Preventing Blood-Brain Barrier Disruption and RIP3-Mediated Necroptosis. | Chen, J., et al. 2019. Cell Transplant. 28: 1358-1372. PMID: 31370690
- Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis. | Urban, C., et al. 2020. Viruses. 12: PMID: 32545331
- Environmental allergens trigger type 2 inflammation through ripoptosome activation. | Brusilovsky, M., et al. 2021. Nat Immunol. 22: 1316-1326. PMID: 34531562
- Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization. | Pan, C., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34782457
- Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death. | Zander, DY., et al. 2022. Cell Death Dis. 13: 364. PMID: 35436994
- Continuous Flow Synthesis of A2E Guided by Design of Experiments and High-Throughput Studies. | Murbach-Oliveira, G., et al. 2022. ACS Bio Med Chem Au. 2: 297-306. PMID: 37101569
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrostatin-7, 5 mg | sc-364122 | 5 mg | $82.00 | |||
Necrostatin-7, 25 mg | sc-364122A | 25 mg | $437.00 |