Molecular structure of Necrostatin-1, inactive control, CAS Number: 64419-92-7
Necrostatin-1, inactive control (CAS 64419-92-7)
See product citations (3)
Alternate Names:
5-(Indol-3-ylmethyl)-2-thiohydantoin; Nec-1i
Application:
Necrostatin-1, inactive control is a cell permeable thiohydantoin analog of Nec-1
CAS Number:
64419-92-7
Purity:
≥95%
Molecular Weight:
245.30
Molecular Formula:
C12H11N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable N-demethylated thiohydantoin analog of Nec-1, devoid of anti-necroptotic properties and serves as a suitable inactive control.
Necrostatin-1, inactive control (CAS 64419-92-7) References
- Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. | Degterev, A., et al. 2005. Nat Chem Biol. 1: 112-9. PMID: 16408008
- Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia. | Chen, R., et al. 2018. Int J Mol Med. 41: 2565-2572. PMID: 29436688
- Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling. | Deng, XX., et al. 2019. Aging Dis. 10: 807-817. PMID: 31440386
- Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications. | Cao, L. and Mu, W. 2021. Pharmacol Res. 163: 105297. PMID: 33181319
- Necrostatin-1 reduces cardiac and mitochondrial dysfunction in prediabetic rats. | Apaijai, N., et al. 2021. J Endocrinol. 251: 27-39. PMID: 34265741
- Necrostatin-1 Prevents Ferroptosis in a RIPK1- and IDO-Independent Manner in Hepatocellular Carcinoma. | Yuk, H., et al. 2021. Antioxidants (Basel). 10: PMID: 34572979
- Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice. | Liu, C., et al. 2022. Neural Regen Res. 17: 2710-2716. PMID: 35662218
- Necrostatin-1 Alleviates Lung Ischemia-Reperfusion Injury via Inhibiting Necroptosis and Apoptosis of Lung Epithelial Cells. | Dong, L., et al. 2022. Cells. 11: PMID: 36231101
- GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. | Liu, M., et al. 2022. J Neuroinflammation. 19: 262. PMID: 36289519
- Necrostatin-1 prevents skeletal muscle ischemia reperfusion injury by regulating Bok-mediated apoptosis. | Cao, Y., et al. 2023. J Chin Med Assoc. 86: 26-33. PMID: 36599139
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrostatin-1, inactive control, 5 mg | sc-204815 | 5 mg | $171.00 |