Molecular structure of Necrostatin-1, CAS Number: 4311-88-0
Necrostatin-1 (CAS 4311-88-0)
See product citations (97)
Alternate Names:
Necrostatin-1 is also known as MTH-DL-Tryptophan.
Application:
Necrostatin-1 is an inhibitor of the necroptosis cell death pathway
CAS Number:
4311-88-0
Purity:
≥95%
Molecular Weight:
259.32
Molecular Formula:
C13H13N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Necrostatin-1 is an organonitrogen and organooxygen compound that is derived from an alpha-amino acid. It is an inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. Additionally, it is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.
Necrostatin-1 (CAS 4311-88-0) References
- Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. | Degterev, A., et al. 2005. Nat Chem Biol. 1: 112-9. PMID: 16408008
- Identification of RIP1 kinase as a specific cellular target of necrostatins. | Degterev, A., et al. 2008. Nat Chem Biol. 4: 313-21. PMID: 18408713
- Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. | Zhu, S., et al. 2011. Cell Death Dis. 2: e115. PMID: 21359116
- A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. | He, W., et al. 2014. Oncogene. 33: 3004-13. PMID: 23831571
- Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice. | Zhou, Y., et al. 2013. Mediators Inflamm. 2013: 706156. PMID: 24198446
- Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. | Zhu, X., et al. 2014. J Cereb Blood Flow Metab. 34: 1531-9. PMID: 24938400
- Inhibitory effects of 3-bromopyruvate in human nasopharyngeal carcinoma cells. | Zou, X., et al. 2015. Oncol Rep. 34: 1895-904. PMID: 26239511
- RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss and Chronic Kidney Disease Progression in Rats. | Zhu, Y., et al. 2016. PLoS One. 11: e0156729. PMID: 27281190
- Inhibiting PSMα-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system. | Zhou, Y., et al. 2018. Cell Death Dis. 9: 362. PMID: 29500427
- Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells. | Zhu, Y., et al. 2020. PLoS One. 15: e0228385. PMID: 32134954
- Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1. | Zhou, T., et al. 2020. Arch Oral Biol. 118: 104858. PMID: 32805637
- Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis. | Zhu, K., et al. 2021. J Immunol Res. 2021: 1815098. PMID: 34307691
- Role and mechanism of necrostin-1 in promoting oxidative stress response of macrophages in high glucose condition. | Zhou, T., et al. 2021. Hua Xi Kou Qiang Yi Xue Za Zhi. 39: 675-681. PMID: 34859627
Inhibitor of:
4930511M11Rik, 4930539E08Rik, 4932412H11Rik, AIFL, Apoptosis, BNIP-2, BNIP-3, caspase-16, CHAC2, DEDD2, EG623459, ENDOG, EVA1A, FAS-L, FBXW26, gasdermin A2, gasdermin A3, GSDMC2, HMG-1, IDO, Nix, Pdcd-7, Programmed cell death (PDCD), reaper, RIP, RIP5, RKIP, TNF-IP 8L2, TRUNDD, and ZBP1.Activator of:
Apoptotic Myeloid Marker, Clusterin, EG432555, Endophilin B1, FBXW2, RIP3, and RIP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrostatin-1, 20 mg | sc-200142 | 20 mg | $94.00 | |||
Necrostatin-1, 100 mg | sc-200142A | 100 mg | $343.00 |