Molecular structure of Necrosis Inhibitor, IM-54, CAS Number: 861891-50-1
Necrosis Inhibitor, IM-54 (CAS 861891-50-1)
See product citations (6)
Alternate Names:
2-(1H-indol-3-yl)-3-pentylamino-maleimide
Application:
Necrosis Inhibitor, IM-54 is a selective inhibitor of oxidative stress-induced necrotic cell death
CAS Number:
861891-50-1
Purity:
≥95%
Molecular Weight:
325.40
Molecular Formula:
C19H23N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Necrosis Inhibitor, IM-54 is a cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 muM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 muM H2O2). Does not offer protection against Etoposide induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 muM.
Necrosis Inhibitor, IM-54 (CAS 861891-50-1) References
- Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. | Dodo, K., et al. 2005. Bioorg Med Chem Lett. 15: 3114-8. PMID: 15878276
- Genetic engineering of Candida utilis yeast for efficient production of L-lactic acid. | Ikushima, S., et al. 2009. Biosci Biotechnol Biochem. 73: 1818-24. PMID: 19661682
- Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. | Lu, CC., et al. 2010. Mol Nutr Food Res. 54: 967-76. PMID: 20169580
- Development of selective inhibitors of necrosis. | Sodeoka, M. and Dodo, K. 2010. Chem Rec. 10: 308-14. PMID: 20848666
- A novel intracellular peptide derived from g1/s cyclin d2 induces cell death. | de Araujo, CB., et al. 2014. J Biol Chem. 289: 16711-26. PMID: 24764300
- Anti-tumor activities of Au(I) complexed with bisphosphines in HL-60 cells. | Hayashi, R., et al. 2014. J Inorg Biochem. 137: 109-14. PMID: 24859826
- Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes. | Lee, H., et al. 2015. PLoS One. 10: e0136122. PMID: 26295477
- Use of the rainbow trout cell lines, RTgill-W1 and RTL-W1 to evaluate the toxic potential of benzotriazoles. | Zeng, F., et al. 2016. Ecotoxicol Environ Saf. 124: 315-323. PMID: 26584462
- Evaluating the toxic potential of benzothiazoles with the rainbow trout cell lines, RTgill-W1 and RTL-W1. | Zeng, F., et al. 2016. Chemosphere. 155: 308-318. PMID: 27131451
- Structure-Activity Relationship Study of 3-Amino-2-indolyllactam Derivatives: Development of Inhibitors of Oxidative Stress-Induced Necrosis. | Dodo, K., et al. 2016. Chem Pharm Bull (Tokyo). 64: 886-98. PMID: 27373644
- Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. | Dodo, K., et al. 2018. ACS Med Chem Lett. 9: 182-187. PMID: 29541357
- Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies. | Korbelik, M., et al. 2020. Photochem Photobiol Sci. 19: 1145-1151. PMID: 32821888
- Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death. | Tomasek, T., et al. 2021. Biochem Biophys Res Commun. 556: 199-206. PMID: 33848934
- Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. | Yu, F., et al. 2022. Chin Med. 17: 115. PMID: 36175965
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Necrosis Inhibitor, IM-54, 1 mg | sc-222053A | 1 mg | $48.00 | |||
Necrosis Inhibitor, IM-54, 5 mg | sc-222053 | 5 mg | $190.00 |