Date published: 2025-12-13

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Nebivolol hydrochloride (CAS 152520-56-4)

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Alternate Names:
(±)-[2R*(1S*5S*(S*))]-α,α′-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Application:
Nebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist
CAS Number:
152520-56-4
Purity:
≥98%
Molecular Weight:
441.9
Molecular Formula:
C22H25F2NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nebivolol hydrochloride is a compound that features both a beta-blocker structure and a hydrochloride salt form, enhancing its solubility and stability. It is utilized in the synthesis of derivatives and analogs within research applications, exploring the modification of its molecular structure for varied interactions and functionalities. The compound′s primary role involves interaction with beta-adrenergic receptors, where it exhibits a selective affinity, facilitating studies focused on receptor dynamics and signaling pathways. Nebivolol hydrochloride distinguishes itself from other beta blockers by stimulating the endothelial nitric oxide synthase (eNOS) enzyme, promoting the release of nitric oxide (NO). These properties make nebivolol hydrochloride a subject of interest in cardiovascular research, where understanding the interplay between beta-adrenergic blockade and endothelial function can provide insights into the management of conditions characterized by increased sympathetic activity and endothelial dysfunction.


Nebivolol hydrochloride (CAS 152520-56-4) References

  1. Involvement of the beta3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta.  |  de Groot, AA., et al. 2003. J Cardiovasc Pharmacol. 42: 232-6. PMID: 12883327
  2. Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension.  |  Georgescu, A., et al. 2007. Eur J Pharmacol. 570: 149-58. PMID: 17612521
  3. A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation.  |  Kamila, MM., et al. 2007. Pharmazie. 62: 486-7. PMID: 17718186
  4. Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors.  |  Georgescu, A., et al. 2008. Pharmacology. 81: 110-7. PMID: 17952013
  5. Determination of nebivolol hydrochloride and hydrochlorothiazide in tablets by first-order derivative spectrophotometry and liquid chromatography.  |  Shah, DA., et al. 2008. J AOAC Int. 91: 1075-82. PMID: 18980121
  6. Stability-Indicating TLC-densitometric determination of nebivolol hydrochloride in bulk and pharmaceutical dosage form.  |  Shirkhedkar, AA., et al. 2010. J Chromatogr Sci. 48: 109-13. PMID: 20109287
  7. Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan using RP HPLC.  |  Kokil, SU. and Bhatia, MS. 2009. Indian J Pharm Sci. 71: 111-4. PMID: 20336202
  8. Stability Indicating RP-HPLC Estimation of Nebivolol Hydrochloride in Pharmaceutical Formulations.  |  Shah, DA., et al. 2008. Indian J Pharm Sci. 70: 591-5. PMID: 21394254
  9. Formulation and evaluation of s-(-)-amlodipine besylate and nebivolol hydrochloride tablets.  |  Shaikh, SA., et al. 2010. J Adv Pharm Technol Res. 1: 199-206. PMID: 22247846
  10. Design, development and permeation studies of nebivolol hydrochloride from novel matrix type transdermal patches.  |  Jatav, VS., et al. 2013. Adv Biomed Res. 2: 62. PMID: 24223377
  11. The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers.  |  Pauwels, PJ., et al. 1988. Mol Pharmacol. 34: 843-51. PMID: 2462161
  12. Second-derivative synchronous spectrofluorimetric determination of nebivolol hydrochloride and amlodipine besylate in their combined dosage form.  |  Ibrahim, F., et al. 2015. Luminescence. 30: 1011-9. PMID: 25727077
  13. Nebivolol attenuates cerebral vasospasm both by increasing endothelial nitric oxide and by decreasing oxidative stress in an experimental subarachnoid haemorrhage.  |  Aladag, MA., et al. 2017. Br J Neurosurg. 31: 439-445. PMID: 28335640
  14. Simultaneous determination of Nebivolol hydrochloride and Valsartan in their binary mixture using different validated spectrophotometric methods.  |  Meselhy, EM., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 230: 118083. PMID: 32004869
  15. Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment.  |  Elsherif, NI., et al. 2021. Pharmaceutics. 13: PMID: 34064916

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nebivolol hydrochloride, 10 mg

sc-204122
10 mg
$147.00

Nebivolol hydrochloride, 50 mg

sc-204122A
50 mg
$350.00