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Neamine hydrochloride (CAS 15446-43-2)

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Alternate Names:
2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine Hydrochloride; Neomycin A Tetrahydrochloride
Application:
Neamine hydrochloride is used in the synthesis of antibacterials
CAS Number:
15446-43-2
Molecular Weight:
468.20
Molecular Formula:
C12H26N4O64HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Neamine hydrochloride is used in the synthesis of antibacterial agents. Neamine is a common structure for aminoglycoside antibiotics. Neamine hydrochloride is a synthetic version of neamine, which is a purine base found in the alkaloid neamine. It is used in laboratory experiments to investigate the structure and function of various biomolecules such as proteins and enzymes. Neamine hydrochloride has also been utilized to examine the relationship between protein and enzyme structure and their activity.


Neamine hydrochloride (CAS 15446-43-2) References

  1. Antidepressant effects of ketamine in depressed patients.  |  Berman, RM., et al. 2000. Biol Psychiatry. 47: 351-4. PMID: 10686270
  2. Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate.  |  Smith, KM., et al. 2002. Am J Health Syst Pharm. 59: 1067-76. PMID: 12063892
  3. Ketamine hydrochloride and its effect on a chronic cobalt epileptic cortical focus.  |  DeVore, GR., et al. 1976. Epilepsia. 17: 111-7. PMID: 1269488
  4. Use of xylazine hydrochloride-ketamine hydrochloride for immobilization of wild leopards (Panthera pardus fusca) in emergency situations.  |  Belsare, AV. and Athreya, VR. 2010. J Zoo Wildl Med. 41: 331-3. PMID: 20597228
  5. Ketamine-snorting associated cystitis.  |  Chen, CH., et al. 2011. J Formos Med Assoc. 110: 787-91. PMID: 22248834
  6. Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain.  |  Guedes, AG., et al. 2012. Am J Vet Res. 73: 610-9. PMID: 22533391
  7. [Ketamine: psychiatric indications and misuses].  |  Delimbeuf, N., et al. 2014. Rev Med Liege. 69: 434-40. PMID: 25158385
  8. Long-term stability of ketamine hydrochloride 50mg/ml injection in 3ml syringes.  |  Huvelle, S., et al. 2016. Ann Pharm Fr. 74: 283-7. PMID: 27107463
  9. A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders.  |  Sanacora, G., et al. 2017. JAMA Psychiatry. 74: 399-405. PMID: 28249076
  10. Anesthetic efficacy of ketamine-diazepam, ketamine-xylazine, and ketamine-acepromazine in Caspian Pond turtles (Mauremys caspica).  |  Adel, M., et al. 2017. Indian J Pharmacol. 49: 93-97. PMID: 28458430
  11. Cardiopulmonary effects of a ketamine hydrochloride/acepromazine combination in healthy cats.  |  Ingwersen, W., et al. 1988. Can J Vet Res. 52: 1-4. PMID: 3127034
  12. Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study.  |  Wang, J., et al. 2019. Drug Des Devel Ther. 13: 4135-4144. PMID: 31827320
  13. Continuous Rate Infusion of Ketamine Hydrochloride and Dexmedetomidine for Maintenance of Anesthesia during Laryngotracheal Surgery in New Zealand White Rabbits (Oryctolagus cuniculus).  |  Sayce, LJ., et al. 2020. J Am Assoc Lab Anim Sci. 59: 176-185. PMID: 32005295
  14. Antidepressant effects of ketamine and ECT: A pilot comparison.  |  Sharma, RK., et al. 2020. J Affect Disord. 276: 260-266. PMID: 32697707
  15. Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice.  |  Xu, W., et al. 2022. Drug Deliv Transl Res. 12: 2518-2526. PMID: 34802093

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Neamine hydrochloride, 50 mg

sc-338357C
50 mg
$199.00

Neamine hydrochloride, 100 mg

sc-338357D
100 mg
$235.00

Neamine hydrochloride, 250 mg

sc-338357
250 mg
$408.00

Neamine hydrochloride, 1 g

sc-338357E
1 g
$1480.00

Neamine hydrochloride, 5 g

sc-338357A
5 g
$4400.00

Neamine hydrochloride, 10 g

sc-338357B
10 g
$7600.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Neamine hydrochloride, sc-338357, is an off-white to yellow to dark yellow powder.
Answered by: Chemical Support 4
Date published: 2017-03-17
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Rated 5 out of 5 by from Liu YP; et alLiu YP; et al. (PubMed ID: 26170989) determined that Neamine hydrochloride significantly reduced the expression of angiogenin and CD31 in prostate cancer cells. -SCBT Publication Review
Date published: 2015-03-25
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Neamine hydrochloride is rated 5.0 out of 5 by 1.
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